Adnexal tumors with differentiation of sebaceous glands D23.L/C44.L

• Heterogeneous group of tumours that originate from the epithelium of the sebaceous gland. With a rather monomorphic and uncharacteristic clinical picture they show an extraordinarily large histological variability, which often makes their exact classification difficult. In addition, there are difficulties due to the different nomenclature. The diagnosis "adnexal tumor with sebaceous gland differentiation" is generally a histological random diagnosis.
• EMA (epithelial membrane antigen) marking can be useful for differentiation of sebocytes.

The classification presented here is essentially based on the morphological criteria developed on the HE section.

• Benign sebaceous growths:
  • Ectopic sebaceous glands
  • Mantelom
  • nevus sebaceus
  • Steatocystoma (older name: Sebocystoma)
  • sebaceous gland hamartoma, follicular, cystic
  • Sebaceous gland hyperplasia (senile)
  • Sebaceous adenoma
  • Sebaceous epithelioma
  • Muir Torre Syndrome.
• Malignant sebaceous growths:
  • Sebaceous carcinoma.

1. Abbott JJ et al (2003) Cystic sebaceous neoplasms in Muir-Torre syndrome. Arch Catholic Lab Med 127: 614-617
2. McBride SR et al (2002) Loss of p21 (WAF1) compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma. J Clin Pathol 55: 763-766
3. Misago N et al (2002) Sebaceoma and related neoplasms with sebaceous differentiation: a clinicopathologic study of 30 cases. At J Dermatopathol 24: 294-304
4. Popnikolov NK et al (2003) Loss of mismatch repair proteins in sebaceous gland tumors. J Cutan Pathol 30: 178-184
5. Zouboulis C et al (2003) Ciclosporin A - induced sebaceous glands hyperplasia. Br J Dermatol 149: 198-200
6. Zutsu T et al (2003) Sebaceous adenoma in the retromolar region: report of a case with a review of the English literature. Int J Oral Maxillofac Surgery 32: 423-426