DefinitionThis section has been translated automatically.
Rare carcinoma of the adnexa with differentiation of sebaceous glands.
ClassificationThis section has been translated automatically.
A distinction is made according to localization:
- Carcinomas of the sebaceous glands localized ocularly
- Extraocularly localized sebaceous gland carcinomas.
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ManifestationThis section has been translated automatically.
Mostly occurring in adults; rare occurrence in children.
LocalizationThis section has been translated automatically.
Mostly located in the periorbital region, but also in the neck. More rarely occurring on the trunk. The occurrence on the oral mucosa, vulva and parotis has also been described.
Clinical featuresThis section has been translated automatically.
Node 0.5-2.0 cm in size. The clinical picture is uncharacteristic and indistinguishable from other malignant non-melanoma tumors of the skin. Mostly appearing as a crusty or ulcerated, red-yellow nodule or correspondingly colored plaque. Individual tumors appear as keratoacanthomas.
Occurrence also described in Muir-Torre syndrome and in nevus sebaceus.
HistologyThis section has been translated automatically.
Asymmetrical, infiltrating tumour with a broad morphological differentiation spectrum from relatively mature (sebocyte-dominated pattern) to immature (basaloid cell type, hardly mature sebocytes; numerous mitoses). The tumor strands are homogeneous, compact, made of basaloid cells with cell and nuclear atypes and numerous mitoses. In addition, mature cell parts with adenoid structural pattern. Nests of mature sebocytes can also occur in these areas. Carcinomas of the sebaceous glands can infiltrate the epidermis pagetoid. In the case of unclear tumours, the EMA immunoperoxidase technique (epithelial membrane antigen) gives good indications of sebocyte differentiation.
Differential diagnosisThis section has been translated automatically.
Clinical:
- Spinocellular carcinoma
- Basal cell carcinoma
- Keratoacanthoma
- Skin metastasis.
Histological:
- Sebaceous gland epithelioma
- Tricholemmal carcinoma
- Clear cell hidradenoma
- Metastasis of renal cell carcinoma.
TherapyThis section has been translated automatically.
The treatment of ocular sebaceous gland carcinomas belongs in the hands of an experienced ophthalmologist. Otherwise, complete surgical excision (see also spinocellular carcinoma) of the primary tumor with a safety margin of at least 1 cm. Edge incision controls necessary. A sentinel lymph node dissection (SNLD) should also be performed.
Progression/forecastThis section has been translated automatically.
Significant metastatic potential. Ocular sebaceous gland carcinomas metastasize or recur in about 30% of cases. The metastasis rate of extraocular tumours is not certain, but lower than that of ocular tumours.
LiteratureThis section has been translated automatically.
- Duman DG et al (2003) Extraorbital sebaceous carcinoma with rapidly developing visceral metastases. Dermatol Surge 29: 987-989
- Handschel J et al (2003) Intraoral sebaceous carcinoma.Br J Oral Maxillofac Surg 41: 84-87
- Khan Z et al (2003) Sebaceous carcinoma of the vulva. BJOG 110: 227-228
- McBride SR et al (2002) Loss of p21(WAF1) compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma. J Clin Pathol 55: 763-736
- Omura NE et al (2002) Sebaceous carcinoma in children. J Am Acad Dermatol 47: 950-953
- Pluot M, Ducasse A. Pathology in the diagnosis and treatment of palpebral tumors. J Fr Ophtalmol 26: 77-83
- Sawada Y et al (2003) Detection by impression cytologic analysis of conjunctival intraepithelial invasion from eyelid sebaceous cell carcinoma. Ophthalmology 110: 2045-2050
- Siriwardena BS et al (2003) A case of sebaceous carcinoma of the parotid gland. J Oral Pathol Med 32: 121-123
- Yamazawa K et al (2003) Sebaceous carcinoma of the uterine cervix: a case report. Int J Gynecol Catholic 22: 92-94
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Incoming links (1)
Muir torre syndrome;Outgoing links (11)
Basal cell carcinoma (overview); Carcinoma of the skin (overview); Clear cell hidradenoma; Keratoakanthoma (overview); Muir torre syndrome; Nevus sebaceus; Pagetoid; Sebaceoma; Sentinel lymph node dissection; Squamous cell carcinoma of the skin; ... Show allDisclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer