Sebaceous adenoma D23.l

Localized mainly on the face, but also in the area of the eyelids, capillitium and neck, rarely on the upper trunk. Rarely also in the area of the oral mucosa.

Mostly solitary, soft, easily distinguishable, skin-coloured or slightly yellowish papules/nodes of 0.5 (maximum) 2.0 cm diameter. The clinical findings are otherwise uncharacteristic. Only the slightly yellowish colour may indicate sebaceous differentiation. In this respect the diagnosis is made histologically.

Notice! Multiple sebaceous gland adenomas in combination with carcinomas of the internal organs are suspected of Muir-Torre syndrome.

Well defined, lobar adenoma in the upper and middle dermis with recognizable differentiation of sebocytes. In addition to sebocytes there are basaloid, basophilic seboblastic cells. The seboblasts condense at the periphery of the lobules to form a multilayer strip. There is extensive contact with the surface epithelium.

Excision if cosmetically disturbing.

1. Abbott JJ et al (2003) Cystic sebaceous neoplasms in Muir-Torre syndrome. Arch Pathol Lab Med 127: 614-617.
2. Boennelycke M et al (2015) Sebaceous neoplasms and the immunoprofile of mismatch-repair proteins as a screening target for syndromic cases. Pathol Res Pract 211:78-82
3. Marques-da-Costa J (2014) Sebaceous adenoma: clinics, dermatoscopy, and histopathology.
4. Int J Dermatol doi: 10.1111/ijd.12722
5. McBride SR et al (2002) Loss of p21(WAF1) compartmentalization in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma. J Clin Pathol 55: 763-766
6. Misago N et al (2002) Sebaceoma and related neoplasms with sebaceous differentiation: a clinicopathologic study of 30 cases. Am J Dermatopathol 24: 294-304
7. Popnikolov NK et al (2003) Loss of mismatch repair proteins in sebaceous gland tumors. J Cutan Pathol 30: 178-184
8. Zutsu T et al (2003) Sebaceous adenoma in the retromolar region: report of a case with a review of the English literature. Int J Oral Maxillofac Surg. 32: 423-426.