Podophylline

Podophyllin (off. DAC86, ÖAB90, Ph. Helv.7.) is a mixture of substances obtained from the ethanolic extract of the rootstock of the plant Podophyllum peltatum in a special process. Podophyllin is a yellow, toxic, amorphous powder that is insoluble in water and partially soluble in ammonia and ethanol. The ingredients are the lignans podophyllotoxin and alpha- and beta-peltatine.

Commission E-Monography: External: pointed condylomas

Experimental medicine: External removal of warts, oncological diseases

Antimitotic effect by binding to tubulin and inhibiting the formation of microtubules.

Medicine: 5% solution 2 times/day for 3 consecutive days for a maximum of 4 weeks, to be applied to the condyloma by a doctor using a cotton swab. Approved for self-therapy. Caution! The treated skin area must not exceed 25 ^cm2. Carefully cover the surrounding skin, e.g. with Pasta zinci mollis. Allow the treated area to dry for at least 1 minute before it comes into contact with clothing.

Cosmetics: The substance is used in cosmetic formulations under the INCI name "Podophyllum peltatum extract". The extract has a skin caring effect.

Notice! Women of childbearing age should use effective contraception under therapy and up to 3 months afterwards!

Condylox® solution (apply twice daily according to the doctor's instructions)

Remember! There are no more ready-to-use drugs available for podophyllin. The prescription can therefore only be made as extemporaneous preparation. Preference should be given to ready-to-use preparations containing podophyllotoxin.