Podophylline

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

Last updated on: 29.10.2020

Synonym(s)

Podophyllinum; Podophyllum peltatum extract; Podophyllum resin; resina podophylli

Definition
This section has been translated automatically.

Podophyllin is a mixture of substances obtained from the ethanolic extract of the rootstock of the plant Podophyllum peltatum in a special process. Podophyllin is a yellow, toxic, amorphous powder insoluble in water, partially soluble in ammonia and ethanol. Ingredients are the lignans podophyllotoxin and alpha - and beta-peltatins.

Pharmacodynamics (Effect)
This section has been translated automatically.

Antimitotic effect by binding to tubulin and inhibiting the formation of microtubules.

You might also be interested in

Dermatology

Lentigo maligna melanoma

Malignant melanoma of elderly people in chronically sun-exposed skin areas. Origins from its precursor lesi...

Advertisment

Indication
This section has been translated automatically.

Means of the reserve for the therapy of condylomata acuminata.

Dosage and method of use
This section has been translated automatically.

Medicine: 5% solution 2 times/day for 3 consecutive days over max. 4 weeks. Let the doctor apply with cotton swab to the condylomas. Caution! The treated skin area must not exceed 25 cm2. Carefully cover the surrounding skin e.g. with pasta zinci mollis. Allow the treated area to dry for at least 1 minute before it comes into contact with clothing.

Cosmetics: The substance is used in cosmetic formulations under the INCI designation "Podophyllum peltatum extract". The extract has a skin caring effect.

Standard concentration
This section has been translated automatically.

Up to 15%.

Undesirable effects
This section has been translated automatically.

Erythema, dermatitis, burning, trophic disorders, necroses and pigmentation, teratogenicity possible, foreskin constriction (due to swelling).

Notice! Women of childbearing age should use effective contraception under therapy and up to 3 months afterwards!

Interactions
This section has been translated automatically.

Alcohol leads to an increase in podophylline toxicity.

Contraindication
This section has been translated automatically.

Pregnancy (teratogenic!), lactation, application to the eye, herpes simplex recidivans, applications in children and adolescents < 18 years, M. Bowen ( tendency to cell dysplasia), immunodeficiency, inflamed or bleeding condylomas, simultaneous treatment with other local therapeutics, positive syphilisserology

Note(s)
This section has been translated automatically.

Remember! There are no more ready-to-use drugs available for podophyllin. The prescription can therefore only be made as extemporaneous preparation. Preference should be given to ready-to-use preparations containing podophyllotoxin.