Podophyllotoxin

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 10.02.2022

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Definition
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Alcoholic extract from the rhizomes of Podophyllum peltatum, s.a.u. Podophyllin.

Commission E- Monograph: external: acute condyloma.

Contained in approved finished medicinal products, see also under phytotherapeutics.

Indication
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Means of the reserve for the therapy of condylomata acuminata.

Dosage and method of use
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Lsg. Apply 2 times/day for 3 consecutive days to condyloma with cotton swab. Approved for self-therapy.

Reminder. The total treated skin area must not exceed 150 mm2. Carefully cover the surrounding skin e.g. with pasta zinci mollis. Allow the treated area to dry for at least 1 min. before contact with clothing.

Standard concentration
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Solution: 0.5%.

Undesirable effects
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Erythema, dermatitis, burning, trophic disorders, necroses and pigmentation, teratogenicity possible, foreskin constriction (due to swelling).

Notice! Women of childbearing age should use effective contraception under therapy and up to 3 months afterwards!

Interactions
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Alcohol leads to an increase in podophyllotoxin toxicity.

Contraindication
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Pregnancy (teratogenic!), lactation, application to the eye, herpes simplex recidivans, children and adolescents < 18 years, M. Bowen ( tendency to cell dysplasia), immunodeficiency, inflamed or bleeding condylomas, simultaneous treatment with other local therapeutic agents, positive syphilisserology .

Preparations
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Condylox® solution; Wartec® cream (0.15%)