Synonym(s)
DefinitionThis section has been translated automatically.
30-50 cm tall poisonous plant from the Berberidaceae family(barberry family), native mainly to North America, with upright stems on which light green, lobed leaves up to 30 cm in diameter are arranged in pairs (see illustration). The plant produces white flowers.
Note(s)This section has been translated automatically.
Podophyllum peltatum is the parent plant of Rhizoma Podophyllii (off. DAC86), an extract obtained from the rhizome of the plant. The ingredients are lignans,
podophyllotoxin, as well as alpha- and beta-peltatine.
Podophyllin is obtained from Rhizoma podophyllii by treating the extract with highly diluted hydrochloric acid, a highly toxic mixture of substances which is used medicinally in ethanolic solution in the treatment of condylomata acuminata.
Partially synthesized podophyllotoxin derivatives are the topoisomerase II inhibitors
- etoposide and
- teniposide
which are used as systemic (non-selective cytotoxic) cytostatics.
Prof. Dr. med. Peter Altmeyer
Prof. Dr. med. Martina Bacharach-Buhles
