Antimycotics

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 07.06.2021

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Definition
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Medicinal products which have either a fungistatic or fungicidal action. See Table 1 for the classification.

Classification
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Polyenes (polyene macrolides)

Azole antifungals

Imidazoles (systemic and local; local in concentrations of 1-2%)

Triazoles (used systemically)

Allylamine

Echinocandins (lipopeptides; inhibitors of glycan synthase)

Morpholine

Various

Indication
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see below Mycoses; see below Dermatomycoses

Literature
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  1. Geier J et al (2016) News on the epicutaneous test series of the German Contact Allergy Group. Dermatology at work and in the environment 64: 70-75

Tables
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Overview of antimycotic drugs and their activity spectra

Group/Substance

Forms of application

Spectrum of action

Dermatophytes

yeasts

Moulds

Polyenes

amphotericin B

top., p.o., i.v.

+

Natamycin

top., p.o.

+

Nystatin

top., p.o.

+

Imidazole

Bifonazole

top.

+

+

+

Clotrimazole

top.

+

+

+

Croconazole

top.

+

+

+

Econazole

top.

+

+

+

Fenticonazole

top.

+

+

+

Isoconazole

top.

+

+

+

Ketoconazole

top., p.o.

+

+

+

Miconazole

top., p.o., i.v.

+

+

+

Oxiconazole

top.

+

+

+

Sertaconazole

top.

+

+

+

Tioconazole

top.

+

+

+

Triazoles

Fluconazole

p.o., i.v.

+

+

(+)

Itraconazole

p.o., i.v.

+

+

+

Voriconazole

p.o., i.v.

+

+

Allylamine

Naftifine

top.

+

Terbinafine

top., p.o.

+

Hydroxypiridone

Ciclopirox

top.

+

+

+

Echinocandine

Caspofungin

i.v.

+

+

Morpholine

Amorolfine

top.

+

+

+

Various

Dequalinium chloride

top.

(+)

+

(+)

Pyrithione Zinc

top.

(+)

+

(+)

Griseofulvin (in D out of trade)

top., p.o.

+

Fenticlor

top.

+

+

Flucytosine

i.v.

(+)

(+)

Tolciclate

top.

+

Tolnaftat

top.

+

Undecylenic acid

top.

+

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Last updated on: 07.06.2021