Ciclopirox

Effective against dermatophytes, yeasts and moulds (DHS). An effectiveness gap as with some azole antifungals or resistances has not been described so far.

Primary fungicidal effect by inhibition of numerous key enzymes of the protein biosynthesis of fungal cells because the m-RNA synthesis is massively disturbed. In addition, the inhibition of catalase leads to H2O2 accumulation within fungal cells, which leads to secondary cell death.

Remarkable is also the antibacterial efficacy (e.g. against accompanying germs in fungal infections). In addition, good anti-inflammatory effect through competitive inhibition of key enzymes (5-lipoxygenase, cyclooxygenase) in the arachidonic acid metabolism. This secondarily inhibits the synthesis of inflammatory mediators such as leukotrienes and prostaglandins.

• Mycoses: Apply a thin layer of cream 1-3 times/day for 3-4 weeks on the affected skin areas, if necessary powder once/day for follow-up treatment.
• In case of candidosis or mycoses of the vagina, apply the applicator filling 1 time per day and insert the vaginal cream deep intravaginally (partner treatment!).
• Tinea unguium: Apply varnish once/day to the affected nail, file the nail once/week, use for a maximum of 6 months.

1% as solution, cream or powder, 1% as vaginal cream, 8% as nail polish (Sonthalia S et al. 2019).

1. Lipner SR et al (2019) Onychomycosis: Treatment and prevention of recurrence. J Am Acad Dermatol 80:853-867.
2. Sonthalia S et al (2019) Topical Ciclopirox Olamine 1%: Revisiting a Unique Antifungal. Indian Dermatol Online J 10: 481-485.