Undecylenic acid

Synonym(s)

10-undecenoic acid; CAS number: 112-38-9; undecylenic acid

Definition
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Undecylenic acid (10-undecenoic acid) is a monounsaturated fatty acid (aliphatic monocarboxylic acid) with a slightly sweaty smell, which is of particular importance in medicine as an antimycotic due to its fungicidal effect.

The fatty acid with the molecular formula C11H202 and the linear formula H2C = CH(CH2)8-COOH, is insoluble in water, soluble in ethyl alcohol, chloroform, ether and benzene. It is a component of the excretion of human sweat glands.

Indication
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Tinea, hyperhidrosis.

Calcium undecylenate (INCI) is a preservative used in cosmetics.

Undecylenic acid monoethanolamide is used for impregnation and washing.

Undecylenic acid ethyl ester is used in 3-5% concentration as an antimycotic(effective against dermatophytes).

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Dosage and method of use
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Cream/Ointment/Solution: Apply thinly to the affected skin areas twice a day for 2-4 weeks. As a hand disinfectant, use undiluted.

Standard concentration
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Cream/ointment/solution: 3-5%, hand disinfectant: 0.1%.

Preparations
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Skinman (combination with propanol and benzalkonium chloride); Estesan cream soap

Note(s)
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The length of 11 carbon atoms of undecylenic acid apparently represents the optimum for the antimycotic effect observed with many fatty acids. Although the antimycotic effect continues to increase with length. However, the increasing, lower solubility in water leads to a reduced bioavailability of the longer fatty acids.