Scillae bulbus

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

Last updated on: 03.03.2023

Synonym(s)

Pancratii veri globe; rustic bulb; scillary bulb; Sea Onion; Urginea maritima; urinary bulb

Definition
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Scillae bulbus, also called sea onion, is a drug monographed by the Commission E, consisting of the dried leaves of the onion of white onion varieties cut into strips. It is used in herbal medicines for the treatment of a mild form of heart failure, among other conditions.

HMPC: not edited

ESCOP: not edited

Commission E-monograph: mild forms of heart failure - also with reduced renal output.

Experimental medicine: digitalis refractory cases, bradycardic form of heart failures, edema.

Ingredients
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Scillae bulbus contains about 30 heart-active glycosides of the budadienolide type, the main glycosides here are scillaren A and proscillaridin a. In addition, scillae bulbus contains flavonoids, anthocyanins and mucilage (glucogalactans) and chellidonic acid.

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Effects
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The glyosides wirekn positive inotropic and negative chronotropic. Scillae bulbus lowers the increased left ventricular end diastolic pressure and pathologically increased venous pressure. The onset of action is rapid.

Field of application/use
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Scillae bulbus is used for a mild form of heart failure (stage I-II NHHA) and edema.

Dosage
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The average daily dose is 0.1 to 0.5 g of adjusted sea onion powder DAB.

Undesirable effects
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Nausea, vomiting, stomach problems, diarrhoea and an irregular pulse may occur.

Contraindication
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In case of existing potassium deficiency or therapy with digitalisglycosides should be avoided.

Interactions
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With a simultaneous administration of quinidine, saluretics, laxatives or a long-term therapy with glucorticoids, the effect and side effects can be intensified.

Trade names
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Finished preparations are not known. Combination preparations with Adonisherb (Adonidis herba)+ Lily of the valley herb(Convalleriae herbae) + Sea onion(Scillae bulbus) +Oleander leaves are widely used (Miroton solution®). Unless otherwise prescribed, adults and adolescents over 12 years of age take 20 - 30 drops 1 - 3 times daily (max. 60 drops daily).

Note(s)
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According to the DAB, the use of sea onion powder can no longer be recommended today, as there are numerous chemical-synthetic drugs which, if relatively well tolerated, can improve the prognosis of heart failure patients.

Finished preparations with sea onion powder are no longer available on the market today.

Literature
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Kaller, H et al. (1956) A German Bulbus Scillae standard preparation. Arzneimittelforschung 6:736-737.
Schilcher H (ed.) in, Leitfaden Phytotherapie, Urban & Fischer Verlag (2016) Munich, pp. 223 f.
Wiesenauer M (2008) PhytoPraxis. Springer Verlag, Heidelberg p.145
Wenigmann M (2017) Phytotherapy medicinal drugs, phytopharmaceuticals, application. Urban & Fischer, pp.158-159
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