Nodular malignant melanoma (amelanotic). 5 months ago first noticed, cherry-sized, slowly size-progressive, superficially completely eroded, moderately shifting, sharply defined nodule with a reddish to skin-colored coloration (right outer ankle of the foot) in an 83-year-old female patient (TD: 5 mm; Clark level IV, pT4b N0 M0; AJCC IIC).
Leprosy. leprosy lepromatosa (-LL-) with large, discreet, somewhat borderline plaque on the cheek and neck. clearly protruding and palpable nerve cord as a sign of lepromatous neuritis.
Melanoma, malignant, nodular: in the centre of the lesion of red surface smooth nodules with peripheral growth, here formation of small clots which are no longer distally connected to the primary tumour (satelliteosis).
Keratoakanthomas, multiple eruptive. suddenly formed, now 1.0 cm in diameter, hard, painless, bowl-shaped node with marginal lip and central horn plug (typical morphology). sliding on the pad. no regional lymph node swelling. in the surrounding area beside single actinic keratoses, several skin-coloured or slightly yellowish solid papules up to 0.4 cm in size (initial keratoakanthomas). 73-year-old patient with long-term immunosuppression (!).
Dermatofibrosarcoma protuberans: Solitary, continuously growing for 4-5 years, difficult to delimit to the side and depth, woody solid, smooth, bumpy, red knot.
Lipoma: A subcutaneous lump on the shoulder that has existed for years, is completely unattractive and asymptomatic, can be easily delimited and slid over the underlying tissue.
Keratoacanthoma: A few months old, initially flat, in the last 2 months strongly progressive in size, coarse knot with a rough edge wall and a blackish (obviously bled into) central horn plug in a 76-year-old man.
Keratoakanthoma, classic type. hard, reddish, hard, reddish, with a central horn plug, grown within a few weeks, measuring about 1.2 cm in diameter, symptomless lump with isolated telangiectasias on the surface, in an 83-year-old female patient. minor pronounced actinic elastosis with a rough wrinkle relief.
Cheilitis actinica chronica. warty, yellowish, firmly adherent, very coarse hyperkeratosis on atrophically diluted, washed-out lip red in chronic actinic cheilitis. a transition to invasive squamous cell carcinoma must be clarified. the upper lip is largely unchanged (lip shadow).
angiofibroma of the oral mucosa: nodularly distended angiofibroma of the oral mucosa. no signs of inflammation, no indication of malignancy. no relevant complaints. differential diagnosis is a mucosal granuloma after bite injury. image from the collection of Dr. Michael Hambardzumyan
Melanoma, malignant, nodular, solitary, solid, sharply defined, surface smooth, non-hairy, black speckled, symptomless lump, growing for more than a year, foundduring routine examination (lump has always been there). Incident light microscopy revealed strong grey-blue streaks and massive pigment network break-ups.
Squamous cell carcinoma of the skin: approx. 3 cm in diameter, coarse, crusty, exuding tumour with an inflammatory reddening of the edges in the area of the neck of a 95-year-old female patient, which empties purulent secretion under pressure.
Verruca seborrhoica. detail magnification: 10 x 7 mm, non-itching, greyish-brown, broad-based plaque with a verrucous, fissured surface. above the tumour there is an artificially caused erythema.
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