Ointments hydrophilic

Definition
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Ointments which consist of a mixture of liquid, low-molecular and solid, higher-molecular macrogols (= polyethylene glycols) and whose consistency is determined by the proportion of higher-molecular polyethylene glycols. As a rule, they are anhydrous (water absorption capacity approx. 15-20%, then liquefaction); they do not require preservation.

Pharmacodynamics (Effect)
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Non-greasy; easily washed off the skin; hydrophilic; osmotic activity against wound secretions; swelling with good diffusion and release capacity for incorporated, dissolved active ingredients.

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Field of application/use
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Ointment base for antiseptic and antimycotic formulations.

Incompatibility
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Light and oxygen lead to the formation of peroxide, which is further converted into aldehydes.
Phenolic substances are chemically bound, partial inactivation of the active ingredient, precipitation at higher concentrations.
Anthrazole, dithranol, oleum thyme, oxytetracycline-HCl, pyrogallol, resorcinol, silver nitrate, sulfonamides and tannin lead to discoloration.
Aluminium chloride and anthrarobin may lead to solidification.
Bacitracin and penicillin are inactivated.
Mercury and silver salts are reduced.
Liq. alum. acet. and terpine hydrate lead to liquefaction.

See Table 1.

Tables
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Compatibility of drugs in macrogol ointment (polyethylene glycol ointment)

Acridine flavinium chloride 2%	dexamethasone 0,1%	neomycin sulfate 0,5%.
allantoin 0,5%	Dexpanthenol 5%	Nicotinic acid benzyl ester 3%.
Ammonium bituminosulphonate 10	Dimetine maleate 1%	nitrofurazone 0,2%
Amphotericin B 3%	Dimeticone 10%	Nystatin 100 000 IU/g
azulene 0,2%	Diphenhydramine HCl 2%	Oleum Pini 1,5
Bamipine HCl 2%	Erythromycin 2%	Pheniramine hydrogen maleate 1,25%
benzalkonium chloride 0,5%.	Ethacridine lactate 1%	Polidocanol 3%
Benzocaine 10%	Eucalyptol 10%	Polyvidon iodine 10%
Benzoic acid 5%	Gentamicin sulphate 0,2	Procaine HCl 2%
Benzoyl peroxide 5%	Urea 10% Urea	Sulphur 5%
Benzyl alcohol 10%	Hydrarg. sulf. rubr. 1%	Sorbic acid 0,1% of
betamethasone-17-valerate 0,1%	hydrocortisone 1%	Sulphadiazine 5%
Bufexamac 5%	hydroxyquinoline sulfate 0,5%.	sulfisomidine 5%
calcium chloride 5%	potassium iodide 3,5%.	tetracaine HCl 0,5
cetylpyridinium chloride 0,5	Camphor 5%	Tetracycline HCl 1%
Chloramine T 5%	Cod liver oil 10%	Tinctura Myrrh 3%
Chloramphenicol 1%	Liq. Carb. deterg. 10%	tretinoin 0.1%
Chlorophenoxamine-HCl 1,5% Chlorophenoxamine-HCl 1,5% Chlorophenoxamine	Menthol 5%	triamcinolone acetonide 0,1
Chlortetracycline HCl 3%	Merbromine 2%	tyrothricin 0,1%
Chrysarobin 5%	Methyl salicylate 5%	Undecylenic acid 5%
Clioquinol 5%	Lactic acid 5	Zinc oxide 10
clotrimazole 1%	Sodium chloride 10	Zinc undecylenate 5%