Benzoyl peroxide

Author: Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

Dieser Artikel auf Deutsch

Synonym(s)

benzoyl peroxide; Benzoyl peroxides; BPO

Definition
This section has been translated automatically.

An active substance belonging to the antimicrobial substances, which is used especially for the therapy of acne.

Pharmacodynamics (Effect)
This section has been translated automatically.

The antimicrobial effect of benzoyl peroxide is based on its oxygen-releasing effect. Propionibacterium acnes requires an anaderobic environment. Benzoyl peroxide has a secondary anti-inflammatory and comedolytic effect (splitting of the disulfide bridges of cysteine).

You might also be interested in

Dermatology

Acne comedonica

Form of Acne vulgaris with a predominant formation of comedones. It should be noted that acne comedonica ma...

Advertisment

Indication
This section has been translated automatically.

Acne comedonica and acne papulopustulosa, seborrhea.

Limited indication
This section has been translated automatically.

Pregnancy, lactation, atopic diathesis, skin erosions.

Dosage and method of use
This section has been translated automatically.

Ointment/gel: Apply thinly 1-2 times/day after thorough skin cleansing to the affected skin areas.
Shampoos: apply 1-2 times/week. Wash emulsion: wash off after a few minutes.
Washing emulsion: wash off after a few minutes.

Standard concentration
This section has been translated automatically.

2.5-10% in water absorbing ointments (absorption bases), ointments, hydrophilic, creams, hydrophobic (W/O emulsion ointments), creams, hydrophilic (O/W emulsion ointments) and gels, hydrophilic. Apply thinly to the affected skin areas 1-2 times/day after thorough skin cleansing.2.5% in shampoos.

Undesirable effects
This section has been translated automatically.

Cross allergy with benzoic acid derivatives, relevant sensitization risk, erythema, skin peeling, skin irritation especially at the beginning of therapy, phototoxicity. Benzoyl peroxides may also cause contact sensitization in orthopedic implants.

Remember! The application can lead to bleaching of hair and textiles!

Contraindication
This section has been translated automatically.

Strong sun exposure, application in the area of mucous membranes, allergy to benzoic acid derivatives.

Incompatibility
This section has been translated automatically.

Alkaline substances.

Preparations
This section has been translated automatically.

Acne Oxide 5%-10%, Acne Oxide L Suspension, Acne Fug Oxide, Cordes BPO, Clin Oxide, Benzacne, Sanoxit, Panoxyl

Note(s)
This section has been translated automatically.

Remember! At concentrations of 65-82% benzoyl peroxide the substance is subject to the Explosives Act.

Literature
This section has been translated automatically.

Bircher A et al (2012) Allergic complications from orthopaedic joint implants: the role of delayed hypersensitivity to benzoyl peroxide in bone cement. Contact Dermatitis 66: 20-26
Felton SJ et al (2013) Benzoyl peroxides in topical acne preparations: an underreported contact allergen? dermatitis 24:146-147
Thomas P et al (2013) Characteristics of 200 patients with suspected implant allergy compared to 100 symptom-free arthroplasty patients. Orthopedist 42: 607-613