Passiflorae herba

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 03.03.2023

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Synonym(s)

Herba Passiflorae; Passionflower herb

Definition
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Passiflorae herba, also called passionflower herb, is a drug consisting of the crushed, flower- or fruit-bearing aerial parts of passionflower. The drug is used to treat nervous restlessness, among other conditions. Positive monographs exist from Commission E, ESCOP and WHO.

HMPC monograph: Traditional-use: to relieve mild stress symptoms, as a sleep aid, approved for nervous restlessness.
ESCOP monograph: for tension, restlessness, excitability, difficulty falling asleep.
Commission E monograph: restlessness.

Empirical medicine: spasmolytic for mild convulsions.

Ingredients
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Passiflorae herba contains coumarin derivatives, up to 2.5 % flavonoids, including above all glucosides of apinine and luteolin, also vitexin. Furthermore protocatechuic acid, caffeic acid, ferulic acid, maltol, small amounts of essential oil and p-hydroxybenzoic acid.

Effects
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Passionflower herb is effective in a weak form against cramps, relieves anxiety and dampens restlessness and also inhibits locomotor activity.

Field of application/use
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Passiflorae herba works according to commission E against nervous restlessness (possibly associated with pectanginous complaints). Further indications are, according to the HMPC-monograph, mild symptoms of mental stress and sleep disorders, and according to the WHO-monograph additionally for nervous stomach complaints.

Dosage
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The daily dose is 4 to 8 g of the drug. As a tea infusion, put 1-2g of drug in 150ml of boiling water, let it steep for 10 minutes, drink 1-4x/day.

The drug is usually used in combination with valerian root, cones, lemon balm leaves (e.g. Sedaselect® N) or hawthorn leaves with flowers (e.g. Passin® Drg).

Undesirable effects
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Rarely nausea or tachycardia. Restriction of fitness to drive and operate machinery

Contraindication
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Allergy to any of the ingredients. The intake is not recommended in children < 12 years (no clinical studies are available). There is also a lack of data on pregnancy and lactation.

Interactions
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There are no known interactions with other drugs.

Recipe(s)
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The fixed combination"Valerian root+hop cone+passion flower herb" from:

has a sedative effect. The combination can also be used in children under 12 years of age.

Literature
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  1. Bhardwaj M et al. (2015) Potential role of vitexin in alleviating heat stress-induced cytotoxicity: Regulatory effect of Hsp90 on ER stress-mediated autophagy. Life Sci 142:36-48.
  2. Chen L et al. (2016) Neuroprotective effects of vitexin against isoflurane-induced neurotoxicity by targeting the TRPV1 and NR2B signaling pathways. Mol Med Rep 14:5607 5613.
  3. He M et al (2016) A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia 115:74-85.
  4. Meng G et al. (2016) Luteolin exerts pro-apoptotic effect and anti-migration effects on A549 lung adenocarcinoma cells through the activation of MEK/ERK signaling pathway. Chem Biol Interact 257:26-34.
  5. Nabavi SF et al (2015) Luteolin as an anti-inflammatory and neuroprotective agent: A brief review. Brain Res Bull 119(Pt A):1-11.
  6. Rosa SI et al (2016) Vitexin reduces neutrophil migration to inflammatory focus by down-regulating pro-inflammatory mediators via inhibition of p38, ERK1/2 and JNK pathway. Phytomedicine 23:9-17.
  7. Schilcher H (2016) In: Leitfaden Phytotherapie, Urban & Fischer Verlag Munich, pp. 240 f.
  8. https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-passiflora-incarnata-l-herba_en.pdf
  9. https://arzneipflanzenlexikon.info/passionflower.php.
  10. Wenigmann M.(2017) Phytotherapy medicinal drugs phytopharmaceuticals application. Urban & Fischer: p 167