Caryophilli flos

Medicinally used constituents of dried flower buds of the clove tree. Monographs on Caryophilli flores are available from Commission E and the WHO, see Caryophylli floris aetheroleum.

The quality is defined in the European Pharmacopoeia.

The essential oil is used phytotherapeutically: clove oil, Caryophylli floris aetheroleum

The active ingredients of Caryophylli flos are different amounts of essential oil (Ph.Eur.8 minimum 15%) with about 85-95% eugenol as main component, 3% oleanolic acid (caryophylline a triterpene apogenin), 6-12% fatty oil, tannins, flavonoids and small amounts of vanillin.

antiseptic, antibacterial, antifungal, antiviral and local anesthetic.

As a stomachic, Caryophilli flos 1-5% is used as mouthwash. In dentistry clove oil is used undiluted for root canal fillings.

In folk medicine it is used for insect bites.

The ingredients of cloves, eugenol and isoeugenol play a major role as allergens. Sensitizing potency: Medium strength. Frequency of sensitization: Occasional. Sensitization ( contact allergy; urticaria) is mainly found on dental material by dental staff. Cross-reactivity exists to Peru Balsam.

Repha-Os® Mouth spray, Salviathymol® drops

1. Adefegha SA et al. (2014) Antihyperglycemic, hypolipidemic, hepatoprotective and antioxidant effects of dietary clove (Szygium aromaticum) bud powder in a high-fat diet/streptozotocin-induced diabetes rat model. J Sci Food Agric 94: 2726-2737
2. Dibazar SP et al. (2014) Immunomodulatory effects of clove (Syzygium aromaticum) constituents on macrophages: in vitro evaluations of aqueous and ethanolic components. J Immunotoxicol 12: 124-131
3. Geier J et al. (2016) Update on the epicutaneous test series of the German Contact Allergy Group. Dermatology in occupation and environment 64: 70-75
4. Hausen BM, Vieluf K (1997) Allergy plants, plant allergens. Ecomed Verlag Landsberg/Munich 224-226
5. Lee JI et al. (2001) Purification and characterization of antithrombotics from Syzygium aromaticum (L.) Merr. & PERRY. Biol Pharm Bull 24: 181-187
6. Mansourian A et al. (2014) The comparative study of antifungal activity of Syzygium aromaticum, Punica granatum and nystatin on Candida albicans; an in vitro study. J Mycol Med 24: e163-168
7. Ranasinghe L (2002) Fungicidal activity of essential oils of Cinnamomum zeylanicum (L.) and Syzygium aromaticum (L.) Merr et L.M. Perry against crown rot and anthracnose pathogens isolated from banana. Lett Appl Microbiol 35: 208-211
8. Sultana B et al. (2015) In vitro antimutagenic, antioxidant activities and total phenolics of clove (Syzygium aromaticum L. seed extracts. Pak J Pharm Sci 27:893-899
9. https://arzneipflanzenlexikon.info/gewuerznelken.php
10. https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-syzygium-aromaticum-l-merill-et-l-m-perry-floris-aetheroleum_en.pdf