Caryophylli floris aetheroleum

Authors: Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 12.04.2025

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Synonym(s)

Clove oil; INCI labeling: Eugenia Caryophyllus

Definition
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Official essential oil (Caryophylli floris aetheroleum) extracted according to Ph.Eur.8 from flower buds, flower stems and leaves of the clove tree.

Clove oil has an unpleasant taste.

The clove oil and the clove itself are used, as well as the eugenol isolated from the clove oil. A distinction is made between the oils of the different parts of the clove plant.

The clove is primarily used to extract eugenol (terpene).

Clove is used in cooking and baking and in the food industry as a flavoring and aromatic substance.

The quality is defined in the European Pharmacopoeia (Ph. Eur.).


HMPC monograph: Traditional-use: mild inflammation of the oral and pharyngeal mucosa, temporary relief of toothache caused by caries.

ESCOP monograph: local anesthetic in dentistry, disinfectant mouthwash, chronic anal fissures
Commission E monograph: inflammatory changes of the oral and pharyngeal mucosa, in dentistry for local pain relief, either undiluted or preparations with up to 30 % essential oil.

Empirical medicine: toothache, stomach ache, flatulence, indigestion. In combination with other phytotherapeutics as a carminative, stomachic or tonic.

Field of application/use
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Essential use in dentistry (e.g. root fillings) or as a flavouring in balsams, tea, etc.

Clove oil has proven to be a simple measure for acute toothache (dilute clove oil 1:1 with water and apply to the painful area).

Undesirable effects
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The DKG has previously tested clove oil 2% in Vaseline. This form of application is no longer available as a test substance in Germany. In this respect, the test substance eugenol 1% in Vaseline is now recommended (as of 2016). Clove oil consists of 90% eugenol, which is also contained in the fragrance mix.

Trade names
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A combination preparation of:

  • anise oil (5 mg per gram) +
  • Bitter fennel oil (10 mg per gram) +
  • Eucalyptus oil (2 mg per gram) +
  • Levomenthol (20 mg per gram) +
  • Clove oil (5 mg per gram) +
  • Peppermint oil (23 mg per gram) +
  • Sage oil (2 mg per gram) +
  • Thymol (1 mg per gram) +
  • Cinnamon oil (2 mg per gram) +

Is commercially available (Saliviathymol® N drops). Dissolve 10 drops in 100ml water, rinse several times with it.

Note(s)
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Clove is used in cooking and baking and in the food industry as a flavouring and odorant. Vanillin and isoeugenol as well as other eugenol derivatives are synthesized from eugenol .

Caution: Tissue irritation when used undiluted.

Literature
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  1. Chen G et al.(1991) Studies on warming the middle-jiao and analgesic effect of flos Caryophylli. Zhongguo Zhong Yao Za Zhi 16:429-432
  2. Gao L et al.(2011) Preparative isolation and purification of five non-volatile compounds from Fructus caryophylli and Flos caryophylli by high-speed counter-current chromatography.Se Pu 29:1112-1117.
  3. Lee KH et al. (1998) Prolyl endopeptidase inhibitors from caryophylli flos. Arch Pharm Res 21:207-211.
  4. https://arzneipflanzenlexikon.info/gewuerznelken.php
  5. https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-syzygium-aromaticum-l-merill-et-l-m-perry-floris-aetheroleum_en.pdf
  6. Blaschek W (2015) Wichtl tea drugs and phytopharmaceuticals. A handbook for practice. Wissenschaftliche Verlagsgesellschaft Munich. S 156-158