Pyrantel

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Broad-spectrum anthelmintic.

Half-life
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26 h

Pharmacodynamics (Effect)
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Spastic paralysis due to depolarisation (neuromuscular blockade) and thus excretion of the worms.

Indication
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Infections caused by Ancylostoma duodenale, Askaridiasis, Enterobius vermicularis, Necator americanus, Trichostrongylus spp.

Limited indication
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pregnancy, liver dysfunction.

Dosage and method of use
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  • Oxyuriasis/Ascariasis:
    • Pat. < 12 kg KG: 125 mg as ED.
    • 12-22 kg bw: 250 mg.
    • 22-40 kg bw: 500 mg.
    • 41-75 kg bw: 750 mg.
    • > 75 kg KG: 1 g.
  • Hookworms: above scheme over 3 days.

Undesirable effects
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Gastrointestinal disorders, increase in transaminases, headaches, dizziness, fatigue, insomnia, allergic skin reactions, fever.

Interactions
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Piperazine and pyrazinobutazone lead to a mutual reduction in effectiveness, the theophylline level is increased.

Contraindication
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Children < 6 months, breastfeeding (take a break!), 1st trimester pregnancy.

Preparations
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Helmex

Outgoing links (3)

Anthelmintics; Askariasis; Theophylline;

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Last updated on: 29.10.2020