Synonym(s)
Acrokeratoelastoidosis Costa; acrokeratoelastoidosis marginalis; Acrokeratoelastoidosis marginalis of the hands; Acrokeratoelastosis; Acrokeratoelastosis of the hands; acrokeratoelastosis verruciformis; Focal acral hyperkeratosis; Keratoelastoidosis; Keratoelastoidosis marginalis manuum; Keratoelastoidosis marginalis of the hands; Palmoplantar keratoderm
HistoryThis section has been translated automatically.
Oswaldo Costa, 1956
DefinitionThis section has been translated automatically.
Autosomal dominant inherited or sporadically occurring (Hussain A et al. 2017), small papular disease (palmoplantar keratosis, classification see below keratosis palmoplantaris) of the hands and feet with signs of a cornification anomaly and elastosis.
The genetic cause of the hereditary form is still unknown.
The "focal acral hyperkeratosis" (see below hyperkeratosis, focal acral) is considered to be a variant. Keratoelastoidosis marginalis (Kocsard 1965) is also a special form of punctate palmoplantar keratosis type 3.
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Occurrence/EpidemiologyThis section has been translated automatically.
More abundant in South America.
ManifestationThis section has been translated automatically.
Especially for people with chronic exposure to sunlight and mechanical stress (people who work outdoors) Usually creeping on in adolescence or in young adulthood.
LocalizationThis section has been translated automatically.
Transition zone from back of the hand to palm, also on the back of the foot and transition zone from back of the foot to soles.
Clinical featuresThis section has been translated automatically.
Often linearly arranged or grouped, skin-coloured, translucent or ivory-coloured, hard horn papules with a shiny smooth surface, possibly lichenoid aspect.
HistologyThis section has been translated automatically.
Orthohyperkeratosis with acanthosis and hypergranulosis. Dermis with signs of actinic damage, evidence of cloddy elastic material in the upper dermis and rarefaction of the elastic fibre network.
Differential diagnosisThis section has been translated automatically.
TherapyThis section has been translated automatically.
No causal therapy known.
LiteratureThis section has been translated automatically.
- Bogle MA et al (2002) Acrokeratoelastoidosis. J Am Acad Dermatol 47: 448-451.
- Costa OG (1956) Acrokerato-elastoidosis. Dermatologica 107: 164-168
- Drobnitsch I et al (1988) Acrokeratoelastoidosis. Dermatologica 39: 311-313
- Erkek E et al (2004) Focal acral hyperkeratosis: a rare cutaneous disorder within the spectrum of Costa acrokeratoelastoidosis. Pediatr Dermatol 21: 128-130
- Highet AS et al (1982) Acrokeratoelastoidosis. Br J Dermatol 106: 337-344
- Hu W et al (2002) Acrokeratoelastoidosis. Pediatr Dermatol 19: 320-322
- Hussain A et al (2017) New-onset acrokeratoelastoidosis in an immunosuppressed patient.
- JAAD Case Rep 4(1):75-76.
- Lewis KG et al (2004) Acquired disorders of elastic tissue: Part II. decreased elastic tissue. J Am Acad Dermatol 51: 165-185.
- Sonthalia S et al (2021) Acrokeratoelastoidosis In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing PMID: 30725752.
- Tajima S et al (2002) A variant of acrokeratoelastoidosis in systemic scleroderma: report of 7 cases. J Am Acad Dermatol 46: 767-770
- Yoshinaga E et al (2003) Acrokeratoelastoidosis associated with nodular scleroderma. Eur J Dermatol 13: 490-492
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Incoming links (10)
Acrokeratodermia hereditaria papulotranslucens; Acrokeratoelastoidosis marginalis; Acrokeratoelastosis; Acrokeratoelastosis of the hands; Acrokeratoelastosis verruciformis; Focal acral hyperkeratosis; Hyperkeratosis, focal acral; Keratoelastoidosis marginalis; Keratoelastoidosis marginalis manuum; Keratoelastoidosis marginalis of the hands;Outgoing links (9)
Acrokeratosis verruciformis; Arsenic keratoses; Dyskeratosis follicularis; Hyperkeratosis, focal acral; Palmoplantar keratoses (overview); Punctate palmoplantar keratoderma; Syphilitic clavi; Verruca vulgaris; Xanthoma;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer
