Synonym(s)
Arsenic warts
DefinitionThis section has been translated automatically.
After years of arsenic intoxication, multiple, punctiform or wartlike keratoses on the hands and feet, in size and number depending on the amount of arsenic absorbed.
LocalizationThis section has been translated automatically.
Especially Palmae and Plantae.
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Clinical featuresThis section has been translated automatically.
Multiple, very rough, yellowish, pinhead to lenticular, flat, possibly confluent, strongly hyperkeratotic papules. Base possibly inflammatory reddened.
HistologyThis section has been translated automatically.
Compact hyperkeratosis, acanthosis, elongation of the reteleal bars. Relatively calm cell picture, but also cell dysplasia up to bowenoid pictures possible.
DiagnosisThis section has been translated automatically.
Search for further cutaneous and internal neoplasia.
Differential diagnosisThis section has been translated automatically.
Complication(s)This section has been translated automatically.
Development of spinocellular carcinomas possible after decades of existence
TherapyThis section has been translated automatically.
In the case of benignity (biopsy), regular check-ups. Individual benign lesions can be removed by curettage under local anaesthetic. In the case of numerous keratoses, keratolysis with e.g. external vitamin A acid (e.g. Cordes VAS, Airol) and mechanical removal after softening of the keratoses with salicylic acid-containing plasters (e.g. Guttaplast) or warm baths with soft soap additive. If malignancy is detected, excision in toto and in sano. If necessary, apply external after-treatment with 5-fluorouracil cream(e.g. Efudix) once/day, for 5 days. Regular tumor aftercare, see below spinocellular carcinoma, M. Bowen.
Note(s)This section has been translated automatically.
Increased exposure to arsenic is known to occur in semiconductor manufacturing, copper and lead production and in the metalworking industry. The cobalt underglaze paints used in the ceramics industry also contain arsenic (Troyanova-Slavkova S et al. 2018).
LiteratureThis section has been translated automatically.
- Ahsan H et al (2003) Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase. Cancer Lett 201: 57-65
- Centeno JA et al (2002) Pathology related to chronic arsenic exposure. Environ Health Perspect 110(Suppl 5): 883-886
- Grobe JW (1992) Arsenic intoxication late sequelae in Moselle vintners. Close to skin Derm 92: 378-387
- Junge J et al (1995) Multiple palmoplantar keratoses, basal cell carcinomas and porocarcinomas after arsenic therapy. Dermatologist 46: 198-201
- Park JY et al (2002) Arsenic keratosis and pigmentation accompanied by multiple Bowen's disease and genitourinary cancer in a psoriasis patient. J Dermatol 29: 446-451
- Troyanova-Slavkova S et al (2018) Squamous cell carcinoma after many years of exposure to arsenic in the porcelain industry Act Dermatol 44: 152-155.
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Incoming links (9)
Arsenic intoxication; Arsenic melanosis; Arsenic warts; Cornu cutaneum; Kaiserstuhl disease; Occupational disease according to bk 1108; Porokeratosis punctata; Punctured palmoplantar keratosis type 3; Verruca plantaris;Outgoing links (13)
Acanthosis; Arsenic intoxication; Bowen's disease; Curettage; Excision; Fluorouracil; Hyperkeratoses; Palmoplantar keratoderma, punctate type 2; Papel; Porokeratosis punctata; ... Show allDisclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer
