Synonym(s)
INAH; INH; Isoniazidium; Isonicotinic acid hydrazide
DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
2.2-7.5 h (slow acetylators), 0.6-2 h (fast acetylators) S.a. under N-acetyltransferases
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IndicationThis section has been translated automatically.
Agent of choice in tuberculosis, only in combination therapies (rapid development of resistance in monotherapy).
Limited indicationThis section has been translated automatically.
Disorders of hematopoiesis.
Dosage and method of useThis section has been translated automatically.
5 mg/kg bw/day p.o. or i.v. for at least 6 months. Children: 10-15 mg/kg bw.
Remember! During pregnancy a combination with ethambutol and rifampicin is possible!
Undesirable effectsThis section has been translated automatically.
Fever, BB changes, gynecomastia, gastrointestinal disorders, liver damage, allergic reactions, drug-induced lupus erythematosus, headaches, dizziness, paresthesias, arthralgias.
InteractionsThis section has been translated automatically.
s. Table 1.
ContraindicationThis section has been translated automatically.
Psychoses, epilepsy, liver and kidney diseases.
PreparationsThis section has been translated automatically.
Isozide, Tebesium
TablesThis section has been translated automatically.
Significant interactions of isoniazid
Alcohol |
Alcohol Tolerance ↓ |
Antiepileptic drugs |
Effect of the antiepileptic drugs ↑ |
β blocker |
Isoniazid mining ↓ |
Carbamazepine |
Carbamazepine levels ↑ |
Insulin |
Isoniazid levels ↑ |
Phenytoin |
Phenytoin effect ↑ |
protionamide |
Protionamide levels ↑ |
Prof. Dr. med. Peter Altmeyer