Synonym(s)
EMB
DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
4–5 h
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Pharmacodynamics (Effect)This section has been translated automatically.
Inhibition of ribosomal RNA synthesis.
IndicationThis section has been translated automatically.
Combination therapy of tuberculosis and therapy-resistant infections caused by atypical mycobacteria.
Limited indicationThis section has been translated automatically.
Restricted kidney function.
Dosage and method of useThis section has been translated automatically.
20 mg/kg bw/day p.o. or i.v., no administration to children.
Notice! During pregnancy administration in combination with isoniazid and rifampicin is possible.
Standard concentrationThis section has been translated automatically.
1-5 ml of a 10% solution for instillation for tuberculous pleuritis.
Undesirable effectsThis section has been translated automatically.
- Cutaneous ADRs: Pruritus, maculopapular exanthema, toxic epidermal necrolysis, among others.
- Extracutaneous ADRs: fever, retrobulbar neuritis with visual impairment and disturbance of red-green vision, hyperuricemia, arthralgias, peripheral neuropathy.
Notice! Regular ophthalmological check-ups are necessary before and during therapy.
InteractionsThis section has been translated automatically.
Delayed absorption of EMB by antacids, cancellation of EMB effect by magnesium, disulfiram increases the risk of N. opticus neuritis
ContraindicationThis section has been translated automatically.
Pre-damage of the optic nerve.
PreparationsThis section has been translated automatically.
EMB-Fatol, Myambutol
Prof. Dr. med. Peter Altmeyer