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Regularly stratified surface epithelium with orthokeratotic keratinization. In the upper and middle dermis, there is a dense patchy infiltrate of slightly vacuolated predominantly mononuclear macrophages (CD68+, only very occasionally S 100+, CD1a-) and lymphocytes; no foam or giant cells. Infiltrate-free border zone below the epidermis.
Electron microscopy: Large numbers of electron-dense, regularly structured "laminated bodies" are seen in the tumor cells, but no Langerhans granules.
Usually no presence of foam cells or giant cells.
Immunohistology: Notice. Histiocytes are positive for Stabilin-1(scavenger receptor protein) and CD68 markers, negative for CD1a and S100 markers(S100 only very occasionally positive).
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- Lan Ma H et al (2006) Successful treatment of generalized eruptive histiocytomas with PUVA. J Dtsch Dermatol Ges 5: 131-114.
- Marzano AV et al (2002) Guess what! Generalized eruptive histiocytosis (histiocytoma). Eur J Dermatol 12: 205-206.
- Matsushima Y et al (1999) Generalized eruptive histiocytoma of childhood associated with rheumatic fever. Eur J Dermatol 9: 548-550.
- Misery L et al (2001) Generalized eruptive histiocytoma in an infant with healing in summer: long-term follow-up. Br J Dermatol 144: 435-437.
- Muller SA et al (1967) Generalized eruptive histiocytoma. Enzyme histochemistry and electron microscopy. Arch Dermatol 96: 11-17
- Utikal J et al (2003) Cutaneous non-Langerhans' cell histiocytoses. J Dtsch Dermatol Ges 1: 471-491.
- Wilk M et al (2016) Generalized Eruptive Histiocytosis With Features of Multinucleate Cell Angiohistiocytoma. Am J Dermatopathol 38:470-472.
- Winkelmann RK et al (1963) Generalized eruptive histiocytoma. A benign papular histiocytic reticulosis. Arch Dermatol 88: 586-596.
- Winkelmann RK, Kossard S, Fraga S (1980) Eruptive histiocytoma of childhood. Arch Dermatol 116: 565-570.
- Zelger BW et al (1996) Non-Langerhans cell histiocytoses. A new unifying concept. Am J Dermatopathol 18: 490-504.
Incoming links (5)
Histiocytoses non-langerhans cell histiocytoses; Histiocytosis, hereditary, progressive, mucinous; Reticulohistiocytosis, multinodular, storing, partly huge; Xanthogranulomas, disseminated adult; Xanthomatosis papular normolipemic;Outgoing links (11)
Cd1a; Cd68; Histiocytoses non-langerhans cell histiocytoses; Immunohistology; Leukaemia acute; Reticulohistiocytosis multicenter; Reticulohistiocytosis, multinodular, storing, partly huge; Rheumatic fever; S100 proteins; Scavenger receptor; ... Show allDisclaimer
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