Taxifolin

Taxifolin is a natural flavonol derivative (see flavonoids). Taxifolin is an essential active ingredient of the fruits of Silybum marinum (see below Silybi mariani fructus) and other plants.

Taxifolin is mainly found in extracts of the Siberian larch (Larix sibirica) from Cercidiphyllum japonicum, the Japanese cake tree, and in fruits of the milk thistle(Silybi mariani fructus).

Taxifolin has antioxidant, antimicrobial, anti-inflammatory and vasodilatory effects.
Taxifolin inhibits platelet function and activation of leukocytes. Taxifolin also inhibits cellular melanogenesis and is comparably effective as arbutin.
Animal experiments have shown that the production of inflammatory cytokines is inhibited after topical application of Taxifolin. Thus Taxifolin inhibits the lipopolysaccharide-induced prostaglandin E2 synthesis via the inhibition of the cyclooxygenase egg.
Taxifolin showed significant hair growth stimulating activities in animal experiments, similar to minoxidil and procyanidin B-2.

1. Ahn JY et al(2010) Effect of taxifolin glycoside on atopic dermatitis-like skin lesions in NC/Nga mice. Phytother Res 24:1071-1077.
2. Lee CW et al (2012) Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoids, and their synthetic derivatives. Bioorg Khim 38:374-381.
3. Oi N et al (2012) Taxifolin suppresses UV-induced skin carcinogenesis by targeting EGFR and PI3K. Cancer Prev Res (Phila)5:1103-1114.
4. Shubina VS et al. (2012) Skin regeneration after chemical burn under the effect of taxifolin-based preparations. Bull Exp Biol Med 154:152-157.