Synonym(s)
Minoxidil hair alcohol 2/5% (NRF 11.121.)
DefinitionThis section has been translated automatically.
Hair restorer, antihypertensive. The active metabolite is minoxidil sulfate. The substance was originally introduced as an antihypertensive (Lonolox). Hypertrichosis, originally known as a side effect, was chosen as an approach for the indication "androgenetic alopecia".
Half-lifeThis section has been translated automatically.
4 h
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Pharmacodynamics (Effect)This section has been translated automatically.
Minoxidil leads to significantly increased hair growth. Proven are:
- Stimulation effects on epidermal and follicular keratinocytes
- Prostaglandin PGH2 Increase
- Increase of VEGF.
Minoxidil belongs to the KATP channel openers just like diazoxide. Minoxidil binds intracellularly to the SHR unit of the potassium channel. The promotion of hair growth is probably also a consequence of the opening of the CATP channels at the hair roots.
IndicationThis section has been translated automatically.
Alopecia androgenetica (see Alopecia androgenetica in women, Alopecia androgenetica in men).
Dosage and method of useThis section has been translated automatically.
Apply 2 times/day to the infested areas.
Standard concentrationThis section has been translated automatically.
2-5% aqueous-alcoholic solution.
Undesirable effectsThis section has been translated automatically.
Local irritation, itching, contact allergic eczema, headache, tachycardia, other cardiovascular symptoms.
Recipe(s)This section has been translated automatically.
PreparationsThis section has been translated automatically.
Regaine® 5% solution; Regaine Women® (2% solution); Bio-H-tin solution ® 20 mg/ml or 50 mg/ml
Note(s)This section has been translated automatically.
Therapeutic success can only be expected under constant application of the preparation.
LiteratureThis section has been translated automatically.
- Messenger AG, Rundegren J (2004) Minoxidil: mechanisms of action on hair growth. Br J Dermatol 150: 186-194
Prof. Dr. med. Peter Altmeyer