Saffron is described as effective in the treatment of a variety of conditions. These include coronary heart disease, eye diseases such as age-related macular degeneration, dry eye syndrome (Crocin) and diabetic maculopathy (Ali S et al (2021). Furthermore, saffron extracts have been used in autoimmune disorders (Korani S et al 2019), arterial hypertension, "gastric distress", dysmenorrhea, and learning and memory disorders (Heitmar R et al 2019).
In addition, several studies have indicated that saffron has pleiotropic anti-inflammatory, anti-oxidant, and neuroprotective effects. The efficiency of C. sativus in the treatment of mild to moderate depression has been described in some clinical studies (Noorbala AA et al. 2005, Khazdair MR et al. 2015).