Passiflorae herba

Authors:Prof. Dr. med. Peter Altmeyer, Prof. Dr. med. Martina Bacharach-Buhles

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Last updated on: 03.03.2023

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Synonym(s)

Herba Passiflorae; Passionflower herb

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DefinitionThis section has been translated automatically.

Passiflorae herba, also called passionflower herb, is a drug consisting of the crushed, flower- or fruit-bearing aerial parts of passionflower. The drug is used to treat nervous restlessness, among other conditions. Positive monographs exist from Commission E, ESCOP and WHO.

HMPC monograph: Traditional-use: to relieve mild stress symptoms, as a sleep aid, approved for nervous restlessness.
ESCOP monograph: for tension, restlessness, excitability, difficulty falling asleep.
Commission E monograph: restlessness.

Empirical medicine: spasmolytic for mild convulsions.

IngredientsThis section has been translated automatically.

Passiflorae herba contains coumarin derivatives, up to 2.5 % flavonoids, including above all glucosides of apinine and luteolin, also vitexin. Furthermore protocatechuic acid, caffeic acid, ferulic acid, maltol, small amounts of essential oil and p-hydroxybenzoic acid.

EffectsThis section has been translated automatically.

Passionflower herb is effective in a weak form against cramps, relieves anxiety and dampens restlessness and also inhibits locomotor activity.

Field of application/useThis section has been translated automatically.

Passiflorae herba works according to commission E against nervous restlessness (possibly associated with pectanginous complaints). Further indications are, according to the HMPC-monograph, mild symptoms of mental stress and sleep disorders, and according to the WHO-monograph additionally for nervous stomach complaints.

DosageThis section has been translated automatically.

The daily dose is 4 to 8 g of the drug. As a tea infusion, put 1-2g of drug in 150ml of boiling water, let it steep for 10 minutes, drink 1-4x/day.

The drug is usually used in combination with valerian root, cones, lemon balm leaves (e.g. Sedaselect® N) or hawthorn leaves with flowers (e.g. Passin® Drg).

Undesirable effectsThis section has been translated automatically.

Rarely nausea or tachycardia. Restriction of fitness to drive and operate machinery

ContraindicationThis section has been translated automatically.

Allergy to any of the ingredients. The intake is not recommended in children < 12 years (no clinical studies are available). There is also a lack of data on pregnancy and lactation.

InteractionsThis section has been translated automatically.

There are no known interactions with other drugs.

Recipe(s)This section has been translated automatically.

The fixed combination"Valerian root+hop cone+passion flower herb" from:

has a sedative effect. The combination can also be used in children under 12 years of age.

LiteratureThis section has been translated automatically.

  1. Bhardwaj M et al. (2015) Potential role of vitexin in alleviating heat stress-induced cytotoxicity: Regulatory effect of Hsp90 on ER stress-mediated autophagy. Life Sci 142:36-48.
  2. Chen L et al. (2016) Neuroprotective effects of vitexin against isoflurane-induced neurotoxicity by targeting the TRPV1 and NR2B signaling pathways. Mol Med Rep 14:5607 5613.
  3. He M et al (2016) A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia 115:74-85.
  4. Meng G et al. (2016) Luteolin exerts pro-apoptotic effect and anti-migration effects on A549 lung adenocarcinoma cells through the activation of MEK/ERK signaling pathway. Chem Biol Interact 257:26-34.
  5. Nabavi SF et al (2015) Luteolin as an anti-inflammatory and neuroprotective agent: A brief review. Brain Res Bull 119(Pt A):1-11.
  6. Rosa SI et al (2016) Vitexin reduces neutrophil migration to inflammatory focus by down-regulating pro-inflammatory mediators via inhibition of p38, ERK1/2 and JNK pathway. Phytomedicine 23:9-17.
  7. Schilcher H (2016) In: Leitfaden Phytotherapie, Urban & Fischer Verlag Munich, pp. 240 f.
  8. https://www.ema.europa.eu/en/documents/herbal-monograph/final-community-herbal-monograph-passiflora-incarnata-l-herba_en.pdf
  9. https://arzneipflanzenlexikon.info/passionflower.php.
  10. Wenigmann M.(2017) Phytotherapy medicinal drugs phytopharmaceuticals application. Urban & Fischer: p 167

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Last updated on: 03.03.2023