Hesperidine

Flavonone derivative, glycoside of hesperetin. The substance is insoluble in water, soluble in ethanol and ether. Hesperedin occurs naturally in the peels of oranges, lemons, bitter oranges and peppers, in addition to its aglycon Hesperetin.
In some orange varieties it makes up to 4.1% of the dry matter in the peel.

Among other things, hesperidin has an antifungal effect and thus protects the plant against fungal infections.
Hesperidin is used medicinally in a combination preparation (together with the flavone glycoside diosmin) for chronic venous insufficiency.
It also has an antioxidant effect and lowers cholesterol and triglyceride levels in the blood.

Hesperidin induces melanin synthesisin melanoma cell cultures by activating tyrosinase activity.

The drug is also widely used as a dietary supplement (due to its effects on blood cholesterol and triglyceride levels).

The derivative of hesperidin, neohesperidin DC, is approved in the EU as a food additive (sweetener).

Hesperidin is also used in cosmetic formulations.

Phlebodril® Kps. (combination with butcher's broom root)

1. Alshatwi AA et al. (2013) The apoptotic effect of hesperetin on human cervical cancer cells is mediated through cell cycle arrest, death receptor, and mitochondrial pathways. Fundam Clin Pharmacol 27:581-592.
2. Palit S et al. (2015) Hesperetin Induces Apoptosis in Breast Carcinoma by Triggering Accumulation of ROS and Activation of ASK1/JNK Pathway. J Cell Physiol 230:1729-1739
3. Usach I et al. (2015) Hesperetin induces
4. Hesperetin induces melanin production in adult human epidermal melanocytes. Food Chem Toxicol.80:80-84.