DefinitionThis section has been translated automatically.
The IFI44 gene (IFI44 stands for: Interferon Induced Protein 44) is a protein-coding gene located on chromosome 1p31.1. An important paralog of this gene is IFI44L.
General informationThis section has been translated automatically.
It is assumed that the encoded protein aggregates and forms microtubular structures. It is thought to be located in the cytosol and is primarily involved in the bacterial immune response.
ClinicThis section has been translated automatically.
Diseases associated with IFI44 include multisystem inflammatory syndrome in children and hepatitis D.
Recent studies have shown that the pathophysiological process for the development of SLE is closely linked to the mutation and abnormal expression of genes including TNFSF4, NCF1-339, CXorf21 and IFI44 and its ligand IFI44L. Various genes have also been discovered for the UV induction of lupus erythematosus. genes have also been discovered that play a role as "UVB response genes (UVBACGs)". These include eight type I interferon-stimulated genes(IRF7, ISG20, ISG15, IFI44, IFITM1, MX1, LY6E, OASL) and 6 others (JUN, PTTG1, HLA-F, CAV1, HOPX, RPL3).
LiteratureThis section has been translated automatically.
- Zhao X et al. (2021) Identification of key biomarkers and immune infiltration in systemic lupus erythematosus by integrated bioinformatics analysis. J Transl Med 19:35.
