DefinitionThis section has been translated automatically.
Penicillin cleavage product.
Half-lifeThis section has been translated automatically.
1–3 h
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IndicationThis section has been translated automatically.
Rheumatoid arthritis, systemic scleroderma, M. Wilson, heavy metal poisoning (lead, mercury, arsenic, copper, zinc).
Limited indicationThis section has been translated automatically.
Age > 65 years, severe infections (temporarily suspend therapy).
Dosage and method of useThis section has been translated automatically.
Remember! Pregnancy must be ruled out before starting therapy. Under the therapy, women must undergo effective contraception!
- Rheumatoid arthritis, systemic scleroderma: initial 150 mg/day p.o., increase by 150 mg/day every 14 days up to 600 mg/day, in the absence of effect further increase up to max. 900-1200 mg/day. At the onset of action, slow dose reduction to a maintenance dose of 300-600 mg/day. Clinical improvement usually occurs only after 2-3 months of therapy. Therapy is discontinued if there is no significant improvement after 3-4 months of taking 900-1200 mg/day.
- M. Wilson: 10-20 mg/kg bw/day p.o.
- Heavy metal poisoning: Initial 4 times/day 250-500 mg p.o. with slow dose reduction.
Standard concentrationThis section has been translated automatically.
2.5% in shampoos for the treatment of green hair discoloured by copper contact.
Undesirable effectsThis section has been translated automatically.
S.u. Penicillin.
InteractionsThis section has been translated automatically.
See Table 1.
ContraindicationThis section has been translated automatically.
Pregnancy, lactation, penicillin hypersensitivity, severe disorders of the hematopoietic system, syst. Lupus erythematosus or high-titre ANAs, simultaneous gold or chloroquine therapy, liver parenchyma damage, renal insufficiency.
PreparationsThis section has been translated automatically.
Metalcaptase
PatientinformationThis section has been translated automatically.
Remember! Take the tablets sober and spread out over the day!
TablesThis section has been translated automatically.
Major interactions of penicillamine
Auranofin |
mutual toxicity ↑ |
Azathioprine |
Penicillamine toxicity ↑ |
Butazone |
Blood formation disorders, kidney damage, avoid combination |
Chloroquine |
Blood formation disorders, avoid combination |
Gold preparations |
Blood formation disorders, kidney damage, avoid combination |
Cytostatic drugs |
Blood formation disorders, kidney damage |
Prof. Dr. med. Peter Altmeyer