Acrodyny T56.11

E.Feer 1923

25 months to 7 years of age.

Initial changes in character: tearfulness, increasing apathy, possibly trichotillomania. After 2-4 weeks cold, moist, cyanotic, swollen hands and feet with coarse lamellar palmoplantar desquamation. Possibly generalized, itchy erythema. Severe hyperhidrosis up to miliaria rubra. In severe cases diffuse alopecia, loss of nails and teeth. Internal symptoms: tachycardia, arterial hypertension, marked fluctuations in blood sugar levels, generalized muscle weakness, sleep disturbances, weight loss. Photophobia, conjunctivitis. Possibly painful paresthesias. The children constantly rub their hands and feet, automutilation occurs.

1. Boyd AS et al (2000) Mercury exposure and cutaneous disease. J Am Acad Dermatol 43(1 Pt 1): 81-90
2. Dinehart MD et al. (1988) Cutaneous manifestation of acrodynia (pink disease). Arch Dermatol 124: 107-109

3. Feer E (1923) On a peculiar neurosis of the vegetative system in infants. Erg.d inn Med u Kinderheilk 24

4. Havarinasab S et al. (2004) Dose-response study of thimerosal-induced murine systemic autoimmunity. Toxicol Appl Pharmacol 194: 169-179
5. Horowitz Y et al (2002) Acrodynia: a case report of two siblings. Arch Dis Child 86: 453
6. Rütter A et al (1996) Metal dermatoses II. Dermatology 47: 400-409

7. Shekhawat R et al (2022) Acrodynia. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. PMID: 32644540.