Vitamin d hypervitaminosis E67.3

Excessive intake of vitamin D accompanied by an increase in serum calcium levels. Vitamin D intoxication is usually observed only at serum 25(OH)D levels above 150ng/ml (374nmol). However, there is evidence that levels > 60ng/ml have an adverse effect on certain chronic diseases.

Discontinue vitamin D substitution. Low calcium diet (no dairy products!). Treatment of hypercalcemia. Forced diuresis with 2-3 l of physiological (0.9%) NaCl solution, with addition of furosemide and potassium if necessary. Systemic administration of glucocorticoids, clodronic acid (e.g., Bonefos) and, if necessary, hemodialysis are further therapeutic options. Cooperation with the internist.

1. KO ML et al (1991) Chronic Vitamin D overdosage: a reminder. Arch Dis Child 66 (8) 1002