Sulfadiazine

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

sulfapyrimidine

Definition
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Half-life
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13–24 h

Indication
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Acute and recurrent toxoplasmosis in combination with pyrimethamine

Dosage and method of use
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  • Adults: Initially 2-4 g, then every 4-6 hours 1 g p.o.
  • Children: 65-150 mg/kg bw/day p.o.

Undesirable effects
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  • Cutaneous ADRs (approx. 10-20% of patients): macular or papular exanthema, angioedema, erythema exsudativum multiforme, photosensitivity.
  • Also: blood count changes (leukopenia, thrombocytopenia), drug fever, headache and joint pain, gastrointestinal side effects such as nausea, diarrhoea, flatulence, vomiting. Rarely cholestatic hepatosis. Hypoglycemia, kidney or liver damage. Very rarely transitory myopia.

Preparations
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sulfadiazine heyl

Outgoing links (2)

Sulfonamides; Toxoplasmosis;

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Last updated on: 29.10.2020