Pyrimethamine

Definition
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Chemotherapy, antimalarials.

> 4 days

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Dermatology

Rare, chronic, bullous, autoimmunological pregnancy dermatosis close to the bullous pemphigoid, occurring p...

Inhibition of dihydrofolate reductase.

In combination with sulfones or sulfonamides effective against all human pathogenic Plasmodium spp., as single agent against Toxoplasma gondii.

In combination preparations for malaria tertiana. Therapy of toxoplasmosis including ocular and congenital manifestations and immunodeficiency.

Pregnancy, folic acid deficiency, liver dysfunction, megaloblastic anemia, renal insufficiency.

Curative malaria therapy (malaria without complications): Application in combination with sulfadoxin (combination preparation: Fansidar contains 500 mg pyrimethamine and 25 mg sulfadoxin): 1500 mg pyrimethamine/75 mg sulfadoxin p.o. as 1-day therapy. Dose reduction for children and adults < 45 kg bw.
Toxoplasmosis (in combination with 4 g sulfadiazin/day p.o.): adults and children > 6 years: 100 mg/day for 3 weeks in combination with folic acid 100 mg/day.
Toxoplasmosis encephalitis in AIDS: 100 mg/day in combination with sulfadiazine and folic acid, followed by recurrent prophylaxis at 50 mg/day.

Remember! Before therapy determination of glucose-6-phosphate dehydrogenase.

Blood count changes, allergic reactions, headaches, heart rhythm disturbances, gastrointestinal complaints, insomnia, dry mouth, shock.

See Table 1.

Severe hematopoiesis, lactation.

Daraprim; Fansidar (combination with sulfadoxine)