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Spindle cell lipomaD17.9
Synonym(s)
HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
The dermal/subcutaneous spindle cell lipoma presents as a painless, solitary, slowly growing, benign, soft nodule.
ManifestationThis section has been translated automatically.
Ratio of men to women = 9:1, most often occurring in middle age (average: 57 years).
LocalizationThis section has been translated automatically.
Mainly the neck or shoulder region is affected; more rarely the upper parts of the trunk. Also located in the area of the oral cavity (tongue). The spindle cell lipoma occurs mainly in the deeper soft tissue.
Clinical featuresThis section has been translated automatically.
Solitary, prallelastic, cutaneous or subcutaneous nodular tumor.
HistologyThis section has been translated automatically.
Well defined, encapsulated tumor containing mature fat cells and uniform, elongated spindle cells within a mucinous matrix. In some areas pure spindle cell populations without fat cells. Palisade formation of spindle cells can lead to misinterpretation with neurogenic tunors. The (very rare) dermal spindle cell lipomas are uncapsulated.
Variable collagen and mucin content, produced by the spindle cells. Mucin can lead to artificial cavities (pseudovascular clefts) when proliferated strongly. Sometimes numerous mast cells within the tumour. The non-lipogenic portions are reactive for CD34, more rarely for desmin; S100 protein is usually non-reactive.
Pleomorphic lipomas contain giant multinuclear cells with rosette-like nuclei.
Cytogenetically, pleomorphic lipomas show recurrent losses on chromosome 16q13-qter, partial losses on 13q and total losses of chomosome 13 (Jäger M 2018).
DiagnosisThis section has been translated automatically.
Differential diagnosisThis section has been translated automatically.
TherapyThis section has been translated automatically.
Progression/forecastThis section has been translated automatically.
The tumour is benign, grows slowly and only in exceptional cases tends to recur postoperatively.
LiteratureThis section has been translated automatically.
- Enzinger FM, Harvey DA (1975) Spindle cell lipoma. Cancer 36: 1852-1859
- Goto T et al (2004) Spindle cell lipoma of the knee: a case report. J Orthop Sci 9: 86-89
- Harvell JD (2003) Multiple spindle cell lipomas and dermatofibrosarcoma protuberans within a single patient: evidence for a common neoplastic process of interstitial dendritic cells? J Am Acad Dermatol 48: 82-85
- Hunter M et al (2018) Pleomorphic lipoma. J Dtsch Dermatol Ges 16: 207-209
- Karim RZ (2003) Intramuscular dendritic fibromyxolipoma: myxoid variant of spindle cell lipoma? Catholic Int 53: 252-528
- Lau SK et al (2015) Spindle cell lipoma of the tongue: a clinicopathologic study of 8 cases and review of the literature. Head neck catholic 9:253-259.
- Machol JA 4th et al. (2015) Spindle Cell Lipoma of the Neck: Review of the Literature and Case Report. Plast Reconstr Surg Glob Open 3:e550.
- Matsushima N et al (2003) Dermal spindle cell lipoma of the posterior neck: CT and MR findings. Eur Radiol 13(Suppl 4): L241-242
- Mentzel T (2000) Lipomatous tumors of the skin and soft tissue. New entities and concepts. Pathologist 2000 21: 441-448
- Nascimento AF et al (2002) Liposarcomas/atypical lipomatous tumors of the oral cavity: a clinicopathologic study of 23 cases. Ann Diagn Pathol 6: 83-93
- Tardio JC et al (2004) Angiomyxolipoma (vascular myxolipoma) of subcutaneous tissue. At J Dermatopathol 26: 222-224