Cd34

Author:Prof. Dr. med. Peter Altmeyer

All authors of this article

Last updated on: 29.10.2020

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DefinitionThis section has been translated automatically.

Acronym for cluster of differentiation 34th CD34 is a marker for: hematopoietic progenitor cells, pluripotent stem cells, capillary endothelial cells, bone marrow stroma cells, acute myeloid and lymphoblastic leukemia/lymphomas.

Structure: transmembrane glycoprotein (110 kDa); Clone: My10

Application: FACS, IHC (P) (G), IF

General informationThis section has been translated automatically.

The highest expressions of CD34 are found on primitive stem cells. They gradually disappear during differentiation and maturation of the precursor cells. About 60% of all acute B-lymphoid leukemias and 40% of acute myeloid leukemias (AML) and up to 5% of acute T-lymphoid leukemias express CD34.

CD 34 is the best marker of dermatofibrosarcoma protuberans. CD34 also marks numerous soft tissue tumors: solitary fibrous tumor, Kaposi's sarcoma, angiosarcoma, neurogenic tumors, spindle cell lipoma, epithelioidal sarcoma.

LiteratureThis section has been translated automatically.

  1. Hantschke M et al (2016) Immunohistological techniques. In: L. Cerroni et al. histopathology of the skin. Springer publishing house Berlin-Heidelberg p. 26-33.

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer