Sebaceous gland hyperplasia diffuse presile D23.L

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Definition
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Seboglandular proliferation disorder with formation of 2-5 mm large yellow papules and seborrhea.

Manifestation
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Occurs in younger to middle age, almost exclusively in men. Also occurring in organ transplant patients under immunosuppression with Ciclosporin A.

Localization
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Face, neck, upper chest.

Clinical features
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Isolated standing or disseminated sowing of densely aggregated, benign, 2-5 mm large, skin-coloured or yellowish-reddish, centrally slightly dented papules. Seborrhoea oleosa.

Differential diagnosis
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Senile sebaceous gland hyperplasia; functional familial sebaceous gland hyperplasia.

External therapy
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Long-term therapy with external agents containing tretinoin (e.g. Cordes VAS cream or gel, e.g. Airol solution 0.05%).

Internal therapy
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In extended cases, isotretinoin (e.g. isotretinoin-ratiopharm; acne normin). Initial sebosuppressive dose of 0.5 mg/kg bw/day, later reduction to 0.3-0.1 mg/kg bw/day. A maintenance dose of 20 mg/day is usually sufficient.

Caution! Anti-conception in women of childbearing age; regular laboratory checks!

Operative therapie
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Electrocautery with pointed needle, laser therapy(Erbium-YAG laser,CO2 laser) or cryosurgery.

Prophylaxis
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Consistent light protection with textile as well as chemical/physical light protection agents (e.g. Anthelios).

Literature
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  1. Kaufmann R (1987) Diffuse (presenile) sebaceous gland hyperplasia, a new entity? dermatologist 38: 31-35
  2. Zouboulis C et al (2003) Ciclosporin A - induced sebaceous glands hyperplasia. Br J Dermatol 149: 198-200

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Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 29.10.2020