Rar-related orphan receptor gamma-t
Synonym(s)
DefinitionThis section has been translated automatically.
Acronym for "RAR-related orphan receptor gamma-t". RAR-related orphan receptor gamma-t (RORgamma-T; RORγt) is a DNA-binding transcription factor, a member of the NR1 subfamily of "nuclear receptors". RORgamma-T, together with its isoform RORgamma1, is encoded by the RORC gene.
The transcription factor is substantially expressed by immature CD4+(Th17 cells) and CD8+ lymphocytes organized in the thymus. The RAR-related orphan receptor gamma-t plays an important role in lymphoid tissue organogenesis in lymph nodes, Peyer's plaques, but not in the spleen. It is important for thymopoiesis by inhibiting apoptosis of undifferentiated T cells on the one hand and promoting their differentiation into Th17 cells on the other hand.
Note(s)This section has been translated automatically.
The protein plays an important role in the pathogenesis of psoriasis and rheumatoid arthritis. Inhibitors of ROR-gamma-t in development appear to be promising in their efficacy.
LiteratureThis section has been translated automatically.
- Eberl G e al. (2004) Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. Science 305: 248-251.
- Huang Z et al (2007) Retinoid-related orphan receptor gamma t is a potential therapeutic target for controlling inflammatory autoimmunity.Expert Opin Ther Targets 11:737-743.
- Preitner N et al (2002) "The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator". Cell 110: 251-260.
- Schäkel K et al (2016) Pathogenesis of psoriasis vulgaris. Dermatologist 67: 422-432
- Sun Z et al (2000) Requirement for RORgamma in thymocyte survival and lymphoid organ development". Science 288: 2369-2373.