Pseudoporphyria E80.25

Polyetiologic, blistering skin disease on sun-exposed skin areas, which leads to a porphyria cutanea tarda-like skin appearance without pathologic porphyrin chemistry. It is characterized by the formation of blisters after bagel injuries, possibly also after sun exposure with subsequent ulcers, hyperkeratosis and scarring.

haemodialysis (in about 16% of patients). Medicines: in 10-12% of children treated with naproxen.

Mostly in chronic renal insufficiency, hemodialysis patients or kidney transplant patients. The existence of pseudoporphyria (in dialysis) has been questioned, as some authors have succeeded in demonstrating an increase in plasma porphyrins (uroporphyrin) in almost all dialysis patients.

Triggering by drugs such as amiodarone, nalidixic acid, diuretics (especially furosemide, bumetanide, thiazides) DADPS, tetracyclines, isotretinoin, 5-fluorouracil, St. John's wort, Ciclosporin A, naproxen (most frequent drug trigger, manifestation often only several months after the start of therapy) and voriconazole has been described.

Intensive UV exposure (solariums) is also the subject of discussion as a triggering co-factor.

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