Synonym(s)
HistoryThis section has been translated automatically.
DefinitionThis section has been translated automatically.
Rare spontaneous or recurrent blistering of the lower legs and/or feet that occurs in diabetics. After 2-6 weeks healing with the development of brownish pigmentation.
Remark: The entity is disputed by some authors
You might also be interested in
Occurrence/EpidemiologyThis section has been translated automatically.
w:m=2:1; average age of onset is 55 years (17-84 years).
EtiopathogenesisThis section has been translated automatically.
Unclear; microtraumas and an underlying microangiopathy are discussed.
ManifestationThis section has been translated automatically.
Mostly occurring in long-term diabetes mellitus (equally in insulin-dependent and insulin-independent diabetes mellitus), especially in patients with polyneuropathy, retinopathy and renal involvement. It is observed in 0.5%-1.0% of diabetics.
LocalizationThis section has been translated automatically.
soles of feet, palms of hands, extensor sides of lower legs, extensor sides of forearms
Clinical featuresThis section has been translated automatically.
Spontaneous blistering of a few millimetres up to several centimetres in the area of the distal extremities, especially the feet. A previous trauma is usually not remembered, although the localizations suggest it. Slight burning sensation.
Clinically important is the association of bullosis diabeticorum with diabetic retinopathy, nephropathy and polyneuropathy. There is no association with insulin dependence.
HistologyThis section has been translated automatically.
- Non-scarring type with intraepidermal cleft or blister formation without acantholysis.
- Scarring type with subepidermal cleft formation.
Differential diagnosisThis section has been translated automatically.
External therapyThis section has been translated automatically.
Internal therapyThis section has been translated automatically.
Setting the diabetes mellitus.
LiteratureThis section has been translated automatically.
- Aye M et al (2002) Dermatological care of the diabetic foot. Am J Clin Dermatol 3: 463-474
- Bernstein JE et al (1983) Reduced threshold to suction-induced blister formation in insulin-dependent diabetics. J Am Acad Dermatol 8: 790-791
- Cantwell AR Jr et al (1967) Idiopathic bullae in diabetics. Bullous diabeticorum. Arch Dermatol 96: 42-44
- Kramer DW (1930) Early or warning signs of impeding gangrene in diabetes. Med J Rec 132: 338-342
- Lipsky BA et al (2000) Diabetic bullae: 12 cases of a purportedly rare cutaneous disorder. Int J Dermatol 39: 196-200
- Ragunatha S et al(2011) Cutaneous disorders in 500 diabetic patients attending diabetic clinic. Indian J Dermatol 56:160-164
- Richardson T, Kerr D (2003) Skin-related complications of insulin therapy: epidemiology and emerging management strategies. At J Clin Dermatol 4: 661-667
Recommended articles
Incoming links (3)
Diabetic blistering; Povidone-iodine ointment 10%, hydrophilic, soft (nrf 11.17.); Quinolinol sulphate monohydrate solution 0,1 % (nrf 11.127.);Outgoing links (7)
Bubble; Epidermolysis bullosa acquisita; Pemphigoid bullous; Polihexanide; Porphyria cutanea tarda; Povidone-iodine ointment 10%, hydrophilic, soft (nrf 11.17.); Pseudoporphyria;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer