Pseudoacanthosis nigricans L83.x

Subtype of Acanthosis nigricans (benigna)

Mainly intertriginous areas (axillae, thigh bends) and lateral cervical area and neck. Less frequently, the non-intertriginous areas of the trunk are affected.

Mostly symmetrical formation of initially yellow-brown to black hyperpigmentations, later on flat, velvety to sour reinforcement of the skin texture, blurred against the surroundings. Mostly hyperhidrosis with corresponding foetor. If the non-intertriginous areas of the trunk are involved, the changes are similar to those of the papillomatosis confluens et reticularis Gougerot Carteaud.

In case of prolonged persistence, development of flat or pendulous fibroma in intertriginous areas.

• intertriginous blurred black-grey verrucous plaques
• symmetrical affection of the axillae and groin regions
• first manifestation already at the age of 17 - 20 years
• very slow development over years
• obesity
• Diabetes mellitus(insulin resistance)
  • not paraneoplastic
  • mostly asymptomatic
  • itching possible

• Ichthyosis vulgaris, autosomal dominant
• Ichthyosis vulgaris, X-linked recessive
• Papillomatosis confluens et reticularis
• Darier's disease
• pemphigus vegetans
• Hailey-Hailey disease

• Local therapy with covering, possibly zinc-containing, powders or creams for dehydration R294 as well as deodorants.
• If necessary, keratolytic external therapy with salicylic acid-containing or urea-containing creams (e.g. Salicylvaseline Lichtenstein, R102 ) as well as low doses of vitamin A acid R256.