Synonym(s)
PTH
DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
2–4 h
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IndicationThis section has been translated automatically.
Combination therapy of tuberculosis, especially for isoniazid resistance.
Limited indicationThis section has been translated automatically.
Chronic alcohol abuse, gastrointestinal ulcers, acute gastritis.
Dosage and method of useThis section has been translated automatically.
- adults: 5-15 mg/kg bw/day p.o. or i.v.
- children: 15-25 mg/kg bw/day p.o./i.v.
- Infants/children: 4 years 25 mg/kg bw/day.
- children 5-8 years 20 mg/kg bw/day.
- children > 9 yrs. 15 mg/kg bw/day.
Undesirable effectsThis section has been translated automatically.
Myelosuppression, hypoglycemia, gynecomastia, hypothyroidism, gastrointestinal disorders, metallic taste, hepatitis, jaundice, allergic reactions, pellagroid symptoms, peripheral and central nervous disorders, dizziness, headache, depression, seizures.
InteractionsThis section has been translated automatically.
See Table 1.
ContraindicationThis section has been translated automatically.
1st trimester pregnancy, lactation, severe liver dysfunction, convulsions, psychosis.
PreparationsThis section has been translated automatically.
Ektebin, Peteha
TablesThis section has been translated automatically.
Major interactions of protionamide
Alcohol |
Central nervous effects ↑ |
Antidiabetic agents, oral |
|
Barbiturates |
Barbiturate degradation ↓ |
Insulin |
|
Isoniazid |
Hepatotoxic and central nervous effects ↑ |
Pyrazinamide |
hepatotoxic effects ↑ |
Rifampicin |
hepatotoxic effects ↑ |
Prof. Dr. med. Peter Altmeyer