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Pilomatrix carcinomaC44.9

Author:Prof. Dr. med. Peter Altmeyer

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Last updated on: 29.10.2020

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Synonym(s)

Carcinoma; maternal carcinoma; matriculation

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HistoryThis section has been translated automatically.

Gromiko, 1927

DefinitionThis section has been translated automatically.

Very rare malignant tumour, originating from the hair follicle apparatus.

ManifestationThis section has been translated automatically.

Usually first appearing between 40th and 60th LJ. Men are affected about 4 times as often as women. According to studies, the age at excision is usually between 40 and 50 LJ.

LocalizationThis section has been translated automatically.

Head (preauricular), neck, back.

Clinical featuresThis section has been translated automatically.

Mostly solitary, 1-10 cm in size, coarse, skin-coloured or yellowish, subcutaneous-cutaneous, blurred, infiltrating with a tendency to ulceration of growing nodules.

HistologyThis section has been translated automatically.

Massive, clumsy, blurred tumor clusters of atypical, very pleomorphic cells with bright cytoplasm and roundish nuclei. Numerous mitoses. Often necrobiotic zones with shadow cells and larger horn masses. Dense lymphocytic infiltrates.

Differential diagnosisThis section has been translated automatically.

Pilomatrixoma; Basal cell carcinoma; Tricholemmal carcinoma.

TherapyThis section has been translated automatically.

Excision with a large safety distance both to the side (1-2 cm) and to the depth (edge cut controls).

Progression/forecastThis section has been translated automatically.

Local recurrences in 50-60% of cases. Metastasis in 5-10% of cases.

LiteratureThis section has been translated automatically.

  1. Ackermann B et al (2001) Neoplasms with follicular differentiation. Ardor Scribendi, New York
  2. Gromiko N (1927) On the knowledge of the malignant transformation of the calcified skin epithelioma. Arch Catholic Anat 265: 103-116
  3. Haferkamp B et al (1999) Pilomatrix carcinoma in an unusual localization. dermatologist 50: 355-359
  4. Hardisson D et al (2002) Pilomatrix carcinoma: a clinicopathologic study of six cases and review of the literature. At J Dermatopathol 23: 394-401
  5. Kaddu S et al (2003) Adnexal tumors with hair follicle differentiation. In: Kerl H et al (ed.) Histopathology of the skin. Springer, Berlin Heidelberg New York, S. 668-669
  6. Petit T et al (2003) Pilomatrix carcinoma: histologic and immunohistochemical features. Two studies. Ann Pathol 23: 50-54

Authors

Last updated on: 29.10.2020

Author: Prof. Dr. med. Peter Altmeyer