Pemphigus drug-induced L10.5

Pathogenetically not clearly clarified disease of the pemphigus group, which was caused by medication.

Various drugs (especially compounds containing sulfhydryl groups such as captopril, D-penicillamine - also penicillins and cephalosporins - or gold compounds) can induce changes that correspond to the different forms of pemphigus. Non-sulfhydryl group-containing drugs such as:

pyrazolone, nifedipine, propanolol, piroxicam, phenobarbital.

In most cases (in about 90% of cases) specific pemphigus AK can be detected. In the absence of AC, acantholysis may be caused by direct reaction of the sulfhydryl groups with disulfide bridges of pemphigus antigens.

Clinically indistinguishable from non-drug pemphigus diseases. Picture of pemphigus vulgaris, pemphigus foliaceus, pemphigus herpetiformis.

1. Ayoub N (2005) Pemphigus and pemphigus-triggering drugs. Ann Dermatol Venereol 132: 595
2. Sugita K et al (2004) D-penicillamine-induced pemphigus successfully treated with combination therapy of mizoribine and prednisolone. J Dermatologist Treat 15: 214-217
3. Goldberg I et al (2005) Pemphigus vulgaris triggered by glibenclamide and cilazapril. Acta Dermatovenerol Croat 13: 153-155

4. Tang X et al (2012) Drug-induced pemphigus after six years of treatment withphenytoin
   and carbamazepine. Int J Dermatol 51:485-486

5. Yoshimura K et al (2014) Clinical and immunological profiles in 17 Japanese patients
   with drug-induced pemphigus studied at Kurume University. Br J Dermatol 171:544-553