Papular dermatitis of pregnancy O26.4

Author: Prof. Dr. med. Peter Altmeyer

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Last updated on: 13.12.2021

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Synonym(s)

Papular dermatitis of pregnancy; Papular dermatitis of pregnancy (PDP); PDP

History
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Spangler et al., 1962

Definition
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Rare, controversial entity associated with pruritic papules (purigoform) pregnancy dermatosis (see below pregnancy, skin lesions).

Remark: possibly a chronic prurigo in pregnancy was described by AS Spangler.

Occurrence/Epidemiology
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Apparently very rare; one disease on 2500 pregnancies (?).

Localization
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Whole integument without special predilection points.

Clinical features
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Recurrent eruptions of intensely pruritic, prurigo-like papules, hemorrhagic crusting, pigmentation.

Laboratory
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Increased choriogonadotropin level in urine, decreased cortisone half-life in serum. Intracutaneous test: Positive reaction against placenta extract from patients with PDP.

Differential diagnosis
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Complication(s)
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In 12% abortion or stillbirth (placental insufficiency?).

External therapy
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Initially, try blanching lotion alba (or ethanolic zinc oxide shake mixture R292 ), emulsions or gels. Cooling gels free of active agents temporarily alleviate the itching. Likewise, cool showers, "cool packs" or moist compresses, e.g. with 0.9% NaCl solution, bring relief.

If not sufficient, antipruriginous additives like polidocanol 3-5% (e.g. Thesit, R200, R197, Optiderm) or tannin 3-5% R247 in lotio alba. Next step are glucocorticoid-containing emulsions like 0,5% hydrocortisone emulsion (e.g. Hydrogalen, R123 ) or hydrocortisone in a cream base (e.g. Hydro Wolff or Hydrophilic Hydrocortisone Acetate Cream NRF11.15.).

Internal therapy
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In severe and intolerable pruritus with significant sleep disturbances, glucocorticoids such as prednisone (e.g. Decortin) 20-40 mg/day with gradual dose reduction according to clinical findings. In severe cases and in the last weeks of pregnancy, additional administration of diphenhydramine HCl(e.g. Vivinox 25-50 mg/day) or benzodiazepines (e.g. diazepam 2-5 mg/day).

The administration of antihistamines in pregnancy is assessed differently in the literature. However, at most preparations of the 1st generation such as clemastine (e.g. Tavegil 2 times/day 1 tbl. p.o. or 2 times/day 1 amp. i.v.) or hydroxyzine (e.g. Atarax 1-3 tbl./day) come into question.

Progression/forecast
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Healing after delivery, recurrence in subsequent pregnancies.

Literature
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  1. Black MM (1989). Prurigo of pregnancy, papular dermatitis of pregnancy, and pruritic folliculitis of pregnancy. Semin Dermatol 8:23-25.
  2. Michaud et al (1982) Papular dermatitis of pregnancy. Arch Dermatol 118: 1003
  3. Moses S (2003) Pruritus. Am Fam Physician 68: 1135-1142
  4. Nguyen LQ et al (1990) Papular dermatitis of pregnancy: a case report. J Am Acad Dermatol 22: 690-691
  5. Spangler AS, Reddy W, Bardawil WA, Roby CC, Emerson K (1962) Papular dermatitis of pregnancy. A new clinical entity? JAMA 181: 577-581

Disclaimer

Please ask your physician for a reliable diagnosis. This website is only meant as a reference.

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Last updated on: 13.12.2021