Microvenular hemangioma D18.0

Very rare, acquired, solitary, benign, slowly growing, asymptomatic vascular tumor.

w:m=6:4.

Most often occurring in young adults (in a larger study, the average was 39 years - 16 months - 69 years). Occurrence associated with POEMS syndrome and pregnancy has been described.

Extremities, preferably forearms, trunk.

Symptomless, red or brown-red, soft or soft-elastic plaque with a smooth surface (rarely larger than 2 cm Ø). Clinically reminiscent of Kaposi's sarcoma. Occasionally occurring together with acute myeloid leukaemia.

Circumscribed, mostly blurred vascular proliferations in the papillary and reticular dermis, with bizarre anastomosing pericyte-rich venules (smooth muscle actin positive) with flattened endothelia and spindle cell nuclei. Condensed collagenous stroma, endothelial atypia, papillae (multilayering) and mitoses are missing.

1. Chang SE et al (2003) Microvenular hemangioma in a boy with acute myelogenous leukemia. Pediatr Dermatol 20: 266-267
2. Ehara Y et al (2019) Multiple microvenular hemangioma eruptively concentrated on an adult face: Importance of clinical differential diagnosis. J Dermatol 46:e205-e206.
3. Fukanaga M, Ushigome S (1998) Microvenular hemangioma. Path Int 48: 237-239
4. Hunt SJ, Santa Cruz DJ, Barr RJ (1991) Microvenular hemangioma. J Cutan Pathol 18: 235-240
5. Kim YC et al (2003) Microvenular hemangioma. Dermatology 206: 161-164
6. Napekoski KM et al (2014) Microvenular hemangioma: aclinicopathologic
   review of 13 cases. J Cutan Pathol 41:816-822.