Mebendazole
DefinitionThis section has been translated automatically.
Half-lifeThis section has been translated automatically.
1,5-5,5 h (metabolites).
Pharmacodynamics (Effect)This section has been translated automatically.
Inhibition of the polymerization of the tubulin structures of the cytoskeleton with inhibition of glucose uptake and the subsequent glycogen processing of the parasites (point of attack: fumarate reductase in the intestine)
IndicationThis section has been translated automatically.
Inoperable or not radically operable forms of Echinococcus cysticus infections(dog tapeworm) and Echinococcus alveolaris infections(fox tapeworm), preoperative support of surgical therapy, trichinosis, treatment attempt for strongyloidosis, cutaneous larva migrans.
Limited indicationThis section has been translated automatically.
Children < 14 years (high dose), liver diseases.
Dosage and method of useThis section has been translated automatically.
See Table 1.
Undesirable effectsThis section has been translated automatically.
Allergic reactions, gastrointestinal complaints (massive infestation and discharge of parasites), BB changes, fever attacks, liver function disorders, hair loss.
InteractionsThis section has been translated automatically.
Cimetidine increases the mebendazole level, the insulin effect is increased, phenytoin reduces the mebendazole effect.
ContraindicationThis section has been translated automatically.
Pregnancy (teratogenic!), lactation, children < 12 months (risk of seizures).
PreparationsThis section has been translated automatically.
Vermox, Surfont
PatientinformationThis section has been translated automatically.
Remember! Take tablets after meals!
TablesThis section has been translated automatically.
Doses of Mebendazole
Indication |
Dosage |
duodenal ancylostoma |
2 times/day 100 mg over 3 days |
Ascaris lumbricoides |
2 times/day 100 mg over 3 days |
Enterobius vermicularis |
100 mg as ED, Wdh. after 14 days or 2 times/day 100 mg over 3 days |
Echinococcus cysticus and granulosus |
2 times/day 500 mg for 3 days, then 3 times/day 500 mg over 3 days, then 3 times/day 13-20 mg/kg bw for 4-6 weeks |
Echinococcus alveolaris and multilocularis |
see above, therapy duration up to 2 years |
Necator americanus |
2 times/day 100 mg over 3 days |
Toxocara spp. |
2 times/day 100-200 mg over 5 days |
Trichinella spp. |
Adults: 4 times/day 20 mg/kg bw for 14 days (plus glucocorticoids) Children: 3 times/day 200-400 mg over 3-6 days, then 3 times/day 400-500 mg over 10 days |
Trichostrongylus |
2 times/day 100 mg over 5 days |
trichuris trichiura |
600 mg/day over 1-3 days or 2 times/day 100 mg over 3 days |