Synonym(s)
Rothmann-Makaish Syndrome; Spontaneous panniculitis Rothmann-Makai
HistoryThis section has been translated automatically.
Rothmann, 1894; Makai, 1928
DefinitionThis section has been translated automatically.
This variant of panniculitis is no longer recognized as an independent disease (Rose C 2018). Originally, lipogranulomatosis subcutanea was defined as idiopathic, focal, chronic panniculitis without general symptoms.
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EtiopathogenesisThis section has been translated automatically.
Idiopathic, a disturbance of the fat composition and focal infections are discussed. Some authors see Lipogranulomatosis subcutanea as afebrile variant of Panniculitis nodularis nonsuppurativa febrilis et recidivans.
ManifestationThis section has been translated automatically.
Occurs mainly in older children and in middle-aged women.
LocalizationThis section has been translated automatically.
Preferably on lower legs; less frequently on trunk or face.
Clinical featuresThis section has been translated automatically.
Suddenly appearing cherry to walnut-sized, subcutaneous, pressure-painful nodules that can be shifted against the skin and pad, or even plate-like hardenings without general symptoms and without involvement of internal organs.
HistologyThis section has been translated automatically.
Lobular panniculitis, focal granulomatous infiltrates, foam cells, giant cells, micropseudocysts.
Differential diagnosisThis section has been translated automatically.
External therapyThis section has been translated automatically.
Cooling, compression bandages. In mild cases, only glucocorticoids externally such as 0.25% prednicarbate (e.g. Dermatop cream) under an occlusion of several hours can be successful. S.a.u. Panniculitis nodularis nonsuppurativa febrilis et recidivans.
Internal therapyThis section has been translated automatically.
Non-steroidal anti-inflammatory drugs such as acetylsalicylic acid (e.g. ASS) or ibuprofen (e.g. Ibuprofen Stada Filmtbl.) In extensive cases systemic glucocorticoids such as prednisolone (e.g. Decortin H) 1 mg/kg bw/day p.o.
Progression/forecastThis section has been translated automatically.
Months to years.
LiteratureThis section has been translated automatically.
- Chan HL (1975) Panniculitis (Rothmann-Makai), with good response to tetracycline. Br J Dermatol 92: 351-354
- Makai E (1928) About Lipogranulomatosis subcutanea. Clin week 7: 2343-2346
- Rose C (2018) Diseases of the fatty tissue. In: Braun-Falco`s Dermatology, Venerology Allergology G. Plewig et al. (Hrsg) Springer Verlag S 1465
- Rothmann M (1894) On inflammation and atrophy of the subcutaneous fatty tissue. Virchows Arch Catholic Anat 136: 159-169
- Tursen U (2003) Rothmann-Makai syndrome with infiltrative ductal mammary cancer: coexistence or association? J Eur Acad Dermatol Venereol 17: 479-480
- Undeutsch W et al. (1970) Lipogranulomatosis Rothmann-Makai independent clinical picture or polyetiological syndrome? Dermatologist 21: 221-225
- Winkelmann RK et al (1989) Lipophagic panniculitis of childhood. J Am Acad Dermatol 21: 971-978
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Incoming links (6)
Lipophagic panniculitis of childhood; Nodular vasculitis; Panniculitis nodularis nonsuppurativa; Rothmann-makaish syndrome; Rothman, stephan; Spontaneous panniculitis rothmann-makai;Outgoing links (10)
Acetylsalicylic acid; Erythema nodosum; Glucocorticosteroids systemic; Gumma; Lipoma (overview); Nodular vasculitis; Panniculitis nodularis nonsuppurativa; Panniculitis (overview); Prednicarbate; Prednisolone;Disclaimer
Please ask your physician for a reliable diagnosis. This website is only meant as a reference.
Prof. Dr. med. Peter Altmeyer