Lipoatrophy, localized after injections T88.7

Side effect in the area of insulin injection sites in diabetics with partly massive skin atrophies 6 months to 2 years after the onset of the insulin response. Lipoatrophies are not only cosmetically disturbing, but can also considerably disturb the absorption kinetics of insulinand cause hyper- or hypoglycemia.

Mainly occurring with the use of insulins with an acidic pH value. Protein impurities contained in insulin are also a conceivable cause. Furthermore, localized drug-induced lipatrophies are observed after injections of glucocorticoids and MS drugs (glatiramer acetate - regular side effect in women).

Mainly occurring in women and children.

injection sites, exceptionally also far from the injection sites.

Changing injection sites. Changing the insulin preparation. Use of a neutral insulin or a monocomponent insulin. S.a.u. Insulin lipoma.

Spontaneous regression within years.

1. Balak DM et al(2012) Cutaneous adverse events associated with disease-modifying treatment in multiple sclerosis: a systematic review. Mult Scler 18:1705-1717