Lipoatrophy, localized after injectionsT88.7
Synonym(s)
DefinitionThis section has been translated automatically.
Side effect in the area of insulin injection sites in diabetics with partly massive skin atrophies 6 months to 2 years after the onset of the insulin response. Lipoatrophies are not only cosmetically disturbing, but can also considerably disturb the absorption kinetics of insulinand cause hyper- or hypoglycemia.
EtiopathogenesisThis section has been translated automatically.
Mainly occurring with the use of insulins with an acidic pH value. Protein impurities contained in insulin are also a conceivable cause. Furthermore, localized drug-induced lipatrophies are observed after injections of glucocorticoids and MS drugs (glatiramer acetate - regular side effect in women).
ManifestationThis section has been translated automatically.
LocalizationThis section has been translated automatically.
TherapyThis section has been translated automatically.
Changing injection sites. Changing the insulin preparation. Use of a neutral insulin or a monocomponent insulin. S.a.u. Insulin lipoma.
Progression/forecastThis section has been translated automatically.
LiteratureThis section has been translated automatically.
- Balak DM et al(2012) Cutaneous adverse events associated with disease-modifying treatment in multiple sclerosis: a systematic review. Mult Scler 18:1705-1717