Single, localized or disseminated, specific, macular, papular or nodular skin infiltrates in the different forms of lymphocytic leukemias.
Primarily seen in patients with B-cell type chronic lymphocytic leukemia (B-CLL).
Less frequently, specific skin infiltrates are seen in:
- acute lymphoblastic leukemia/lymphoma
- T-cell large lymphocytic leukemia
- prolymphocytic leukemia
- T-cell leukemia with large granular lymphocytes and
- hairy cell leukemia.
In most cases, specific skin infiltrates are found in the presence of pre-existing, hematologically oncologically proven underlying disease. Rarely they precede the manifest lymphatic systemic disease.