All, skin manifestations C83.5
Synonym(s)
Acute lymphatic leukemia; lymphoblastic leukemia; lymphoblastic lymphosarcoma; malignant lymphoma with small non cleaved follicle center cells; Paramyeloblastic leukemia; Stem cell leukemia
DefinitionThis section has been translated automatically.
Lymphoma of high malignancy, which can immunologically show B (B-LBL), or T cells (T-LBL) Specific skin lesions are rare.
ManifestationThis section has been translated automatically.
Especially occurring in children.
Clinical featuresThis section has been translated automatically.
Solitary, but also multiple nodes of different sizes, often ulcerated.
HistologyThis section has been translated automatically.
Regardless of their provenance (B or T cells) similar histological pattern: Dense, diffuse, monomorphic infiltrate in dermis and subcutis. Sometimes starry sky-like pattern (starry sky). Cytomorphologically, medium or large cell lymphoblasts are found, with round or angular nuclei with irregularly distributed chromatin, usually narrow cytoplasmic border, interspersed with large macrophages.
Immunohistology:
B-LBL: positive for: CD20, CD10, CD43, CD34.
T-LBL: positive for: CD1a, CD3, CD43; negative for B-cell markers
Differential diagnosisThis section has been translated automatically.
Myelomonocytic leukemias; mantle cell lymphoma; Merkel cell tumor;
skin metastases of a small cell bronchial carcinoma.
skin metastases of a small cell bronchial carcinoma.
LiteratureThis section has been translated automatically.
- Kaddu S, Cerroni L, Kerl H (2003) Leukemias of the skin. In: Kerl H et al (ed.) Histopathology of the skin. Springer publishing house, Berlin Heidelberg New York, S. 917-919